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Crystal structure of pre-activated arrestin p44

Author

Listed:
  • Yong Ju Kim

    (Institut für Medizinische Physik und Biophysik (CC2), Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany)

  • Klaus Peter Hofmann

    (Institut für Medizinische Physik und Biophysik (CC2), Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany
    Zentrum für Biophysik und Bioinformatik, Humboldt-Universität zu Berlin, Invalidenstrasse 42, D-10115 Berlin, Germany)

  • Oliver P. Ernst

    (University of Toronto, 1 King’s College Circle)

  • Patrick Scheerer

    (Institut für Medizinische Physik und Biophysik (CC2), AG Protein X-ray Crystallography, Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany)

  • Hui-Woog Choe

    (Institut für Medizinische Physik und Biophysik (CC2), Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany
    College of Natural Science, Chonbuk National University)

  • Martha E. Sommer

    (Institut für Medizinische Physik und Biophysik (CC2), Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany)

Abstract

The crystal structure of arrestin-1 is reported, in which the activation step is mimicked by C-tail truncation; the structure of this pre-activated arrestin is markedly different from the basal state and gives an insight into the activation mechanism.

Suggested Citation

  • Yong Ju Kim & Klaus Peter Hofmann & Oliver P. Ernst & Patrick Scheerer & Hui-Woog Choe & Martha E. Sommer, 2013. "Crystal structure of pre-activated arrestin p44," Nature, Nature, vol. 497(7447), pages 142-146, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7447:d:10.1038_nature12133
    DOI: 10.1038/nature12133
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