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Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

Author

Listed:
  • Muhammed Murtaza

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Sarah-Jane Dawson

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK)

  • Dana W. Y. Tsui

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Davina Gale

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Tim Forshew

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Anna M. Piskorz

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Christine Parkinson

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK)

  • Suet-Feung Chin

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Zoya Kingsbury

    (Illumina, Inc., Chesterford Research Park, Little Chesterford CB10 1XL, UK)

  • Alvin S. C. Wong

    (National University Cancer Institute, National University Health System, 5 Lower Kent Ridge Road, Tower block level 7, 119074 Singapore)

  • Francesco Marass

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Sean Humphray

    (Illumina, Inc., Chesterford Research Park, Little Chesterford CB10 1XL, UK)

  • James Hadfield

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • David Bentley

    (Illumina, Inc., Chesterford Research Park, Little Chesterford CB10 1XL, UK)

  • Tan Min Chin

    (National University Cancer Institute, National University Health System, 5 Lower Kent Ridge Road, Tower block level 7, 119074 Singapore
    Cancer Science Institute, National University of Singapore, Centre for Translational Medicine, 14 Medical Drive, #12-01, 117599 Singapore)

  • James D. Brenton

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
    Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK)

  • Carlos Caldas

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
    Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK)

  • Nitzan Rosenfeld

    (Cancer Research UK Cambridge Institute and University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

Abstract

A proof of principle study shows that by exome sequencing of cell-free circulating DNA from cancer patient plasma samples, the genomic evolution of metastatic cancers and the acquisition of resistance in response to therapy can be tracked over time.

Suggested Citation

  • Muhammed Murtaza & Sarah-Jane Dawson & Dana W. Y. Tsui & Davina Gale & Tim Forshew & Anna M. Piskorz & Christine Parkinson & Suet-Feung Chin & Zoya Kingsbury & Alvin S. C. Wong & Francesco Marass & Se, 2013. "Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA," Nature, Nature, vol. 497(7447), pages 108-112, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7447:d:10.1038_nature12065
    DOI: 10.1038/nature12065
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    Cited by:

    1. Nailil Husna & Tatsuya Aiba & Shin-Ichiro Fujita & Yoshika Saito & Dai Shiba & Takashi Kudo & Satoru Takahashi & Satoshi Furukawa & Masafumi Muratani, 2024. "Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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