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Tension sensing by Aurora B kinase is independent of survivin-based centromere localization

Author

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  • Christopher S. Campbell

    (University of California San Diego)

  • Arshad Desai

    (University of California San Diego)

Abstract

The current model to explain accurate chromosome segregation after DNA replication holds that kinetochore–microtubule attachments exert tension across the centromere and are stabilized by spatial separation from inner centromere-localized Aurora B; here an alternative model is presented, wherein active Aurora B produced by clustering is sufficient to ensure biorientation through a mechanism that is intrinsic to the kinetochore.

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  • Christopher S. Campbell & Arshad Desai, 2013. "Tension sensing by Aurora B kinase is independent of survivin-based centromere localization," Nature, Nature, vol. 497(7447), pages 118-121, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7447:d:10.1038_nature12057
    DOI: 10.1038/nature12057
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    Cited by:

    1. Anna K. Regt & Cordell J. Clark & Charles L. Asbury & Sue Biggins, 2022. "Tension can directly suppress Aurora B kinase-triggered release of kinetochore-microtubule attachments," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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