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Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

Author

Listed:
  • Heping Xu

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Xuanying Li

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Dan Liu

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Jianfu Li

    (School of Medicine, Tsinghua University
    Present address: Department of Oral and Maxillofacial Surgery, The Methodist Hospital Research Institute, Houston, Texas 77030, USA.)

  • Xu Zhang

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Xin Chen

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Shiyue Hou

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Lixia Peng

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

  • Chenguang Xu

    (School of Life Sciences, Tsinghua University)

  • Wanli Liu

    (School of Life Sciences, Tsinghua University)

  • Lianfeng Zhang

    (Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College)

  • Hai Qi

    (Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University)

Abstract

ICOS ligand expression by bystander B cells is shown to induce pseudopod extension and migration of CXCR5-expressing T-helper cells into B-cell follicles, where they provide help to cognate B cells for germinal centre development.

Suggested Citation

  • Heping Xu & Xuanying Li & Dan Liu & Jianfu Li & Xu Zhang & Xin Chen & Shiyue Hou & Lixia Peng & Chenguang Xu & Wanli Liu & Lianfeng Zhang & Hai Qi, 2013. "Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility," Nature, Nature, vol. 496(7446), pages 523-527, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7446:d:10.1038_nature12058
    DOI: 10.1038/nature12058
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    Cited by:

    1. Liat Stoler-Barak & Ethan Harris & Ayelet Peres & Hadas Hezroni & Mirela Kuka & Pietro Lucia & Amalie Grenov & Neta Gurwicz & Meital Kupervaser & Bon Ham Yip & Matteo Iannacone & Gur Yaari & John D. C, 2023. "B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Fangming Zhu & Ryan J. McMonigle & Andrew R. Schroeder & Xianyou Xia & David Figge & Braxton D. Greer & Edahí González-Avalos & Diego O. Sialer & Yin-Hu Wang & Kelly M. Chandler & Adam J. Getzler & Em, 2023. "Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4+ T cell fate," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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