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Crystal structure of a eukaryotic phosphate transporter

Author

Listed:
  • Bjørn P. Pedersen

    (University of California)

  • Hemant Kumar

    (University of California
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India)

  • Andrew B. Waight

    (University of California)

  • Aaron J. Risenmay

    (University of California)

  • Zygy Roe-Zurz

    (University of California)

  • Bryant H. Chau

    (University of California)

  • Avner Schlessinger

    (California Institute for Quantitative Biosciences, University of California)

  • Massimiliano Bonomi

    (California Institute for Quantitative Biosciences, University of California)

  • William Harries

    (University of California)

  • Andrej Sali

    (California Institute for Quantitative Biosciences, University of California)

  • Atul K. Johri

    (School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India)

  • Robert M. Stroud

    (University of California)

Abstract

The X-ray crystal structure of a high-affinity phosphate importer in an inward-facing, occluded state in the presence of phosphate is reported; this is the first structure of a membrane protein involved in inorganic phosphate uptake and the first crystal structure of a eukaryotic MFS transporter.

Suggested Citation

  • Bjørn P. Pedersen & Hemant Kumar & Andrew B. Waight & Aaron J. Risenmay & Zygy Roe-Zurz & Bryant H. Chau & Avner Schlessinger & Massimiliano Bonomi & William Harries & Andrej Sali & Atul K. Johri & Ro, 2013. "Crystal structure of a eukaryotic phosphate transporter," Nature, Nature, vol. 496(7446), pages 533-536, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7446:d:10.1038_nature12042
    DOI: 10.1038/nature12042
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    Cited by:

    1. Jody L. Andersen & Gui-Xin He & Prathusha Kakarla & Ranjana KC & Sanath Kumar & Wazir Singh Lakra & Mun Mun Mukherjee & Indrika Ranaweera & Ugina Shrestha & Thuy Tran & Manuel F. Varela, 2015. "Multidrug Efflux Pumps from Enterobacteriaceae, Vibrio cholerae and Staphylococcus aureus Bacterial Food Pathogens," IJERPH, MDPI, vol. 12(2), pages 1-61, January.

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