IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v496y2013i7446d10.1038_nature11984.html
   My bibliography  Save this article

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

Author

Listed:
  • Chuan Wu

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Nir Yosef

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
    Broad Institute of MIT and Harvard, 7 Cambridge Center)

  • Theresa Thalhamer

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
    Present address: Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.)

  • Chen Zhu

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Sheng Xiao

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Yasuhiro Kishi

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Aviv Regev

    (Broad Institute of MIT and Harvard, 7 Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

  • Vijay K. Kuchroo

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
    Broad Institute of MIT and Harvard, 7 Cambridge Center)

Abstract

Transcriptional profiling of developing TH17 cells identifies serum glucocorticoid kinase 1 (SGK1) as an essential node downstream of IL-23 signalling, and transcriptional analysis shows that a modest increase in salt concentration induces SGK1 expression, promotes IL-23 receptor expression and enhances TH17 cell differentiation, accelerating the development of autoimmunity.

Suggested Citation

  • Chuan Wu & Nir Yosef & Theresa Thalhamer & Chen Zhu & Sheng Xiao & Yasuhiro Kishi & Aviv Regev & Vijay K. Kuchroo, 2013. "Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1," Nature, Nature, vol. 496(7446), pages 513-517, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7446:d:10.1038_nature11984
    DOI: 10.1038/nature11984
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11984
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11984?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Srikanth Sadhu & Rajdeep Dalal & Jyotsna Dandotiya & Akshay Binayke & Virendra Singh & Manas Ranjan Tripathy & Vinayaka Das & Sandeep Goswami & Shakti Kumar & Zaigham Abbas Rizvi & Amit Awasthi, 2023. "IL-9 aggravates SARS-CoV-2 infection and exacerbates associated airway inflammation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:496:y:2013:i:7446:d:10.1038_nature11984. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.