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Visualization of an endogenous retinoic acid gradient across embryonic development

Author

Listed:
  • Satoshi Shimozono

    (Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan)

  • Tadahiro Iimura

    (Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan)

  • Tetsuya Kitaguchi

    (Life Function and Dynamics, ERATO, JST, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan)

  • Shin-ichi Higashijima

    (National Institutes of Natural Sciences, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, Okazaki, Aichi, 444-8787, Japan)

  • Atsushi Miyawaki

    (Laboratory for Cell Function Dynamics, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan
    Life Function and Dynamics, ERATO, JST, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan)

Abstract

Genetically encoded probes for the non-peptidic morphogen retinoic acid allow the quantitative measurement of physiological RA concentration in vivo; the results support the source–sink diffusion model of morphogen dynamics proposed by Francis Crick in 1970.

Suggested Citation

  • Satoshi Shimozono & Tadahiro Iimura & Tetsuya Kitaguchi & Shin-ichi Higashijima & Atsushi Miyawaki, 2013. "Visualization of an endogenous retinoic acid gradient across embryonic development," Nature, Nature, vol. 496(7445), pages 363-366, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7445:d:10.1038_nature12037
    DOI: 10.1038/nature12037
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