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Diverse and heritable lineage imprinting of early haematopoietic progenitors

Author

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  • Shalin H. Naik

    (The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Present address: Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.)

  • Leïla Perié

    (The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH Utrecht, The Netherlands)

  • Erwin Swart

    (The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands)

  • Carmen Gerlach

    (The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands)

  • Nienke van Rooij

    (The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands)

  • Rob J. de Boer

    (Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH Utrecht, The Netherlands)

  • Ton N. Schumacher

    (The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands)

Abstract

In vivo ‘cellular barcoding’ shows that early haematopoietic progenitors are heterogeneous in the cell types that they produce, and this is partly due to an ‘imprinting’ of fate in progenitors, including for a separate dendritic cell lineage.

Suggested Citation

  • Shalin H. Naik & Leïla Perié & Erwin Swart & Carmen Gerlach & Nienke van Rooij & Rob J. de Boer & Ton N. Schumacher, 2013. "Diverse and heritable lineage imprinting of early haematopoietic progenitors," Nature, Nature, vol. 496(7444), pages 229-232, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7444:d:10.1038_nature12013
    DOI: 10.1038/nature12013
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    Cited by:

    1. Konstantin Lutz & Andrea Musumeci & Christopher Sie & Ezgi Dursun & Elena Winheim & Johannes Bagnoli & Christoph Ziegenhain & Lisa Rausch & Volker Bergen & Malte D. Luecken & Robert A. J. Oostendorp &, 2022. "Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Jos Urbanus & Jason Cosgrove & Joost B. Beltman & Yuval Elhanati & Rafael A. Moral & Cecile Conrad & Jeroen W. Heijst & Emilie Tubeuf & Arno Velds & Lianne Kok & Candice Merle & Jens P. Magnusson & Lé, 2023. "DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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