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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Author

Listed:
  • G. M. Tannahill

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland)

  • A. M. Curtis

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland)

  • J. Adamik

    (Duquesne University)

  • E. M. Palsson-McDermott

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland)

  • A. F. McGettrick

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland)

  • G. Goel

    (Centre for Computational and Integrative Biology, Massachusetts General Hospital, Richard B. Simches Research Center)

  • C. Frezza

    (Apoptosis and Tumour Physiology Laboratory, The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK
    Medical Research Council Cancer Cell Unit Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0X2, UK)

  • N. J. Bernard

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland)

  • B. Kelly

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland)

  • N. H. Foley

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland)

  • L. Zheng

    (Apoptosis and Tumour Physiology Laboratory, The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK)

  • A. Gardet

    (The Broad Institute of MIT and Harvard, 7 Cambridge Center)

  • Z. Tong

    (Cornell University)

  • S. S. Jany

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland)

  • S. C. Corr

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland)

  • M. Haneklaus

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland)

  • B. E. Caffrey

    (Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland)

  • K. Pierce

    (The Broad Institute of MIT and Harvard, 7 Cambridge Center)

  • S. Walmsley

    (Academic Unit of Respiratory Medicine, University of Sheffield, Sheffield S10 2RX, UK)

  • F. C. Beasley

    (V. Nizet Laboratory, Centre for Neural Circuits and Behaviour, University of California)

  • E. Cummins

    (Conway Institute, University College Dublin, Dublin 4, Ireland)

  • V. Nizet

    (V. Nizet Laboratory, Centre for Neural Circuits and Behaviour, University of California)

  • M. Whyte

    (Academic Unit of Respiratory Medicine, University of Sheffield, Sheffield S10 2RX, UK)

  • C. T. Taylor

    (Conway Institute, University College Dublin, Dublin 4, Ireland)

  • H. Lin

    (Cornell University)

  • S. L. Masters

    (Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia)

  • E. Gottlieb

    (Apoptosis and Tumour Physiology Laboratory, The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK)

  • V. P. Kelly

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland)

  • C. Clish

    (The Broad Institute of MIT and Harvard, 7 Cambridge Center)

  • P. E. Auron

    (Duquesne University)

  • R. J. Xavier

    (Centre for Computational and Integrative Biology, Massachusetts General Hospital, Richard B. Simches Research Center
    Medical Research Council Cancer Cell Unit Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0X2, UK)

  • L. A. J. O’Neill

    (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland)

Abstract

Succinate is identified as a metabolite in innate immune signalling, which leads to enhanced interleukin-1β production during inflammation.

Suggested Citation

  • G. M. Tannahill & A. M. Curtis & J. Adamik & E. M. Palsson-McDermott & A. F. McGettrick & G. Goel & C. Frezza & N. J. Bernard & B. Kelly & N. H. Foley & L. Zheng & A. Gardet & Z. Tong & S. S. Jany & S, 2013. "Succinate is an inflammatory signal that induces IL-1β through HIF-1α," Nature, Nature, vol. 496(7444), pages 238-242, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7444:d:10.1038_nature11986
    DOI: 10.1038/nature11986
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    Cited by:

    1. Shiman Zuo & Yuxin Wang & Hanjing Bao & Zehui Zhang & Nanfei Yang & Meng Jia & Qing Zhang & Ani Jian & Rong Ji & Lidan Zhang & Yan Lu & Yahong Huang & Pingping Shen, 2024. "Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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