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SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

Author

Listed:
  • Hong Jiang

    (Cornell University)

  • Saba Khan

    (Cornell University)

  • Yi Wang

    (University of Hong Kong)

  • Guillaume Charron

    (The Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA)

  • Bin He

    (Cornell University)

  • Carlos Sebastian

    (The Massachusetts General Hospital Cancer Center, Harvard Medical School, 185 Cambridge St., Boston, Massachusetts 02114, USA)

  • Jintang Du

    (Cornell University)

  • Ray Kim

    (Cornell University)

  • Eva Ge

    (Cornell University)

  • Raul Mostoslavsky

    (The Massachusetts General Hospital Cancer Center, Harvard Medical School, 185 Cambridge St., Boston, Massachusetts 02114, USA)

  • Howard C. Hang

    (The Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA)

  • Quan Hao

    (University of Hong Kong)

  • Hening Lin

    (Cornell University)

Abstract

The sirtuin family of enzymes are known as NAD-dependent deacetylases, although some of them have very weak deacetylase activity; here human SIRT6, an enzyme important for DNA repair and transcription, is shown to remove long-chain fatty acyl groups from protein lysine residues, and to have a function in promoting tumour necrosis factor alpha secretion.

Suggested Citation

  • Hong Jiang & Saba Khan & Yi Wang & Guillaume Charron & Bin He & Carlos Sebastian & Jintang Du & Ray Kim & Eva Ge & Raul Mostoslavsky & Howard C. Hang & Quan Hao & Hening Lin, 2013. "SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine," Nature, Nature, vol. 496(7443), pages 110-113, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7443:d:10.1038_nature12038
    DOI: 10.1038/nature12038
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    Cited by:

    1. Miao Wang & Yugang Zhang & Garrison P. Komaniecki & Xuan Lu & Ji Cao & Mingming Zhang & Tao Yu & Dan Hou & Nicole A. Spiegelman & Ming Yang & Ian R. Price & Hening Lin, 2022. "Golgi stress induces SIRT2 to counteract Shigella infection via defatty-acylation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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