IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v496y2013i7443d10.1038_nature11998.html
   My bibliography  Save this article

Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

Author

Listed:
  • Wei-chen Chang

    (College of Pharmacy, University of Texas at Austin
    Present addresses: Department of Chemistry, Penn State University, University Park, Pennsylvania 16802, USA (W.-c.C.); Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA (M.D.); Department of Chemistry, Boston University, Boston, Massachusetts 02215, USA (P.L.); Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, USA (S.O.M.); Agensys, Santa Monica, California 90404, USA (S.-J.M.); Department of Biotechnology, Dalian Institute of Chemical Physics, Dalian 116023, China (Z.K.Z.).)

  • Mishtu Dey

    (Massachusetts Institute of Technology
    Present addresses: Department of Chemistry, Penn State University, University Park, Pennsylvania 16802, USA (W.-c.C.); Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA (M.D.); Department of Chemistry, Boston University, Boston, Massachusetts 02215, USA (P.L.); Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, USA (S.O.M.); Agensys, Santa Monica, California 90404, USA (S.-J.M.); Department of Biotechnology, Dalian Institute of Chemical Physics, Dalian 116023, China (Z.K.Z.).)

  • Pinghua Liu

    (College of Pharmacy, University of Texas at Austin
    Present addresses: Department of Chemistry, Penn State University, University Park, Pennsylvania 16802, USA (W.-c.C.); Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA (M.D.); Department of Chemistry, Boston University, Boston, Massachusetts 02215, USA (P.L.); Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, USA (S.O.M.); Agensys, Santa Monica, California 90404, USA (S.-J.M.); Department of Biotechnology, Dalian Institute of Chemical Physics, Dalian 116023, China (Z.K.Z.).)

  • Steven O. Mansoorabadi

    (College of Pharmacy, University of Texas at Austin
    Present addresses: Department of Chemistry, Penn State University, University Park, Pennsylvania 16802, USA (W.-c.C.); Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA (M.D.); Department of Chemistry, Boston University, Boston, Massachusetts 02215, USA (P.L.); Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, USA (S.O.M.); Agensys, Santa Monica, California 90404, USA (S.-J.M.); Department of Biotechnology, Dalian Institute of Chemical Physics, Dalian 116023, China (Z.K.Z.).)

  • Sung-Ju Moon

    (College of Pharmacy, University of Texas at Austin
    Present addresses: Department of Chemistry, Penn State University, University Park, Pennsylvania 16802, USA (W.-c.C.); Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA (M.D.); Department of Chemistry, Boston University, Boston, Massachusetts 02215, USA (P.L.); Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, USA (S.O.M.); Agensys, Santa Monica, California 90404, USA (S.-J.M.); Department of Biotechnology, Dalian Institute of Chemical Physics, Dalian 116023, China (Z.K.Z.).)

  • Zongbao K. Zhao

    (College of Pharmacy, University of Texas at Austin
    Present addresses: Department of Chemistry, Penn State University, University Park, Pennsylvania 16802, USA (W.-c.C.); Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA (M.D.); Department of Chemistry, Boston University, Boston, Massachusetts 02215, USA (P.L.); Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, USA (S.O.M.); Agensys, Santa Monica, California 90404, USA (S.-J.M.); Department of Biotechnology, Dalian Institute of Chemical Physics, Dalian 116023, China (Z.K.Z.).)

  • Catherine L. Drennan

    (Massachusetts Institute of Technology)

  • Hung-wen Liu

    (College of Pharmacy, University of Texas at Austin)

Abstract

The non-haem-iron-dependent enzyme HppE catalyses the final step in the biosynthesis of fosfomycin, a broad-spectrum, clinically useful antibiotic; here it is shown that HppE can also catalyse a 1,2-phosphono-migration reaction, previously undocumented for any enzyme.

Suggested Citation

  • Wei-chen Chang & Mishtu Dey & Pinghua Liu & Steven O. Mansoorabadi & Sung-Ju Moon & Zongbao K. Zhao & Catherine L. Drennan & Hung-wen Liu, 2013. "Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction," Nature, Nature, vol. 496(7443), pages 114-118, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7443:d:10.1038_nature11998
    DOI: 10.1038/nature11998
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11998
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11998?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:496:y:2013:i:7443:d:10.1038_nature11998. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.