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A syringe-like injection mechanism in Photorhabdus luminescens toxins

Author

Listed:
  • Christos Gatsogiannis

    (Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany)

  • Alexander E. Lang

    (Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany)

  • Dominic Meusch

    (Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany)

  • Vanda Pfaumann

    (Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany)

  • Oliver Hofnagel

    (Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany)

  • Roland Benz

    (School of Engineering and Science, Jacobs University Bremen, Campusring 1, 28759 Bremen, Germany)

  • Klaus Aktories

    (Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany)

  • Stefan Raunser

    (Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany)

Abstract

The TcA component of Photorhabdus luminescens ABC-type toxin complexes forms a transmembrane pore and injects TcC, the functional component of the toxin, into the target cell by means of a syringe-like mechanism.

Suggested Citation

  • Christos Gatsogiannis & Alexander E. Lang & Dominic Meusch & Vanda Pfaumann & Oliver Hofnagel & Roland Benz & Klaus Aktories & Stefan Raunser, 2013. "A syringe-like injection mechanism in Photorhabdus luminescens toxins," Nature, Nature, vol. 495(7442), pages 520-523, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7442:d:10.1038_nature11987
    DOI: 10.1038/nature11987
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    Cited by:

    1. B. U. Klink & A. Alavizargar & K. S. Kalyankumar & M. Chen & A. Heuer & C. Gatsogiannis, 2024. "Structural basis of α-latrotoxin transition to a cation-selective pore," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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