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A central role for TFIID in the pluripotent transcription circuitry

Author

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  • W. W. M. Pim Pijnappel

    (Molecular Cancer Research, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Netherlands Proteomics Center, 3584 CH Utrecht, The Netherlands
    Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    Present addresses: Department of Pediatrics and Department of Clinical Genetics, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands (W.W.M.P.P.; A.J.B.; E.v.d.W.); Department of Stem Cell Biology, School of Medicine, SMART Institute of Advanced Biomedical Science, Konkuk University, 143701 Seoul, Republic of Korea (D.W.H.).)

  • Daniel Esch

    (Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany)

  • Marijke P. A. Baltissen

    (Molecular Cancer Research, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Netherlands Proteomics Center, 3584 CH Utrecht, The Netherlands)

  • Guangming Wu

    (Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany)

  • Nikolai Mischerikow

    (Netherlands Proteomics Center, 3584 CH Utrecht, The Netherlands
    Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands)

  • Atze J. Bergsma

    (Molecular Cancer Research, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Present addresses: Department of Pediatrics and Department of Clinical Genetics, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands (W.W.M.P.P.; A.J.B.; E.v.d.W.); Department of Stem Cell Biology, School of Medicine, SMART Institute of Advanced Biomedical Science, Konkuk University, 143701 Seoul, Republic of Korea (D.W.H.).)

  • Erik van der Wal

    (Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany
    Present addresses: Department of Pediatrics and Department of Clinical Genetics, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands (W.W.M.P.P.; A.J.B.; E.v.d.W.); Department of Stem Cell Biology, School of Medicine, SMART Institute of Advanced Biomedical Science, Konkuk University, 143701 Seoul, Republic of Korea (D.W.H.).)

  • Dong Wook Han

    (Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany
    Present addresses: Department of Pediatrics and Department of Clinical Genetics, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands (W.W.M.P.P.; A.J.B.; E.v.d.W.); Department of Stem Cell Biology, School of Medicine, SMART Institute of Advanced Biomedical Science, Konkuk University, 143701 Seoul, Republic of Korea (D.W.H.).)

  • Hermann vom Bruch

    (Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany)

  • Sören Moritz

    (Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany)

  • Phillip Lijnzaad

    (Molecular Cancer Research, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands)

  • A. F. Maarten Altelaar

    (Netherlands Proteomics Center, 3584 CH Utrecht, The Netherlands
    Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands)

  • Katrin Sameith

    (Molecular Cancer Research, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands)

  • Holm Zaehres

    (Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany)

  • Albert J. R. Heck

    (Netherlands Proteomics Center, 3584 CH Utrecht, The Netherlands
    Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands)

  • Frank C. P. Holstege

    (Molecular Cancer Research, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands)

  • Hans R. Schöler

    (Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany)

  • H. T. Marc Timmers

    (Molecular Cancer Research, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Netherlands Proteomics Center, 3584 CH Utrecht, The Netherlands)

Abstract

High levels of TFIID, a basal transcription factor, are found to be essential to induce and maintain the transcriptional program of pluripotent cells.

Suggested Citation

  • W. W. M. Pim Pijnappel & Daniel Esch & Marijke P. A. Baltissen & Guangming Wu & Nikolai Mischerikow & Atze J. Bergsma & Erik van der Wal & Dong Wook Han & Hermann vom Bruch & Sören Moritz & Phillip Li, 2013. "A central role for TFIID in the pluripotent transcription circuitry," Nature, Nature, vol. 495(7442), pages 516-519, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7442:d:10.1038_nature11970
    DOI: 10.1038/nature11970
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