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Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

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  • Tim J. Schulz

    (Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
    Present address: Research Group Adipocyte Development, German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal 14558, Germany.)

  • Ping Huang

    (Boston Children’s Hospital, Harvard Medical School)

  • Tian Lian Huang

    (Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School)

  • Ruidan Xue

    (Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
    Huashan Hospital, Shanghai Medical College, Fudan University)

  • Lindsay E. McDougall

    (Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School)

  • Kristy L. Townsend

    (Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School)

  • Aaron M. Cypess

    (Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School)

  • Yuji Mishina

    (School of Dentistry, University of Michigan)

  • Emanuela Gussoni

    (Boston Children’s Hospital, Harvard Medical School)

  • Yu-Hua Tseng

    (Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School
    Harvard Stem Cell Institute, Harvard University)

Abstract

A shortage of constitutive brown adipose tissue is shown to result when brown adipogenic progenitor cells lack a type of BMP receptor; however, this leads to an increase in sympathetic input to white adipose tissue and a compensatory browning of white fat depots.

Suggested Citation

  • Tim J. Schulz & Ping Huang & Tian Lian Huang & Ruidan Xue & Lindsay E. McDougall & Kristy L. Townsend & Aaron M. Cypess & Yuji Mishina & Emanuela Gussoni & Yu-Hua Tseng, 2013. "Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat," Nature, Nature, vol. 495(7441), pages 379-383, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7441:d:10.1038_nature11943
    DOI: 10.1038/nature11943
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    Cited by:

    1. Xun Huang & Xinmeng Li & Hongyu Shen & Yiheng Zhao & Zhao Zhou & Yushuang Wang & Jingfei Yao & Kaili Xue & Dongmei Wu & Yifu Qiu, 2023. "Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Hyuek Jong Lee & Jueun Lee & Myung Jin Yang & Young-Chan Kim & Seon Pyo Hong & Jung Mo Kim & Geum-Sook Hwang & Gou Young Koh, 2023. "Endothelial cell-derived stem cell factor promotes lipid accumulation through c-Kit-mediated increase of lipogenic enzymes in brown adipocytes," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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