IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v495y2013i7441d10.1038_nature11925.html
   My bibliography  Save this article

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

Author

Listed:
  • Yael Costa

    (Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Junjun Ding

    (Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine)

  • Thorold W. Theunissen

    (Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Francesco Faiola

    (Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine)

  • Timothy A. Hore

    (Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK)

  • Pavel V. Shliaha

    (Cambridge Centre for Proteomics, Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Miguel Fidalgo

    (Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine)

  • Arven Saunders

    (Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine)

  • Moyra Lawrence

    (Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Sabine Dietmann

    (Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Satyabrata Das

    (and Program in Molecular and Cellular Biology, University of Iowa)

  • Dana N. Levasseur

    (and Program in Molecular and Cellular Biology, University of Iowa)

  • Zhe Li

    (Indiana University)

  • Mingjiang Xu

    (Indiana University)

  • Wolf Reik

    (Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK
    Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK)

  • José C. R. Silva

    (Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Jianlong Wang

    (Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine)

Abstract

The authors show that the pluripotency factor NANOG interacts with TET1 and TET2 methylcytosine hydroxylases, and that the hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine enhances the efficiency of somatic cell reprogramming in a NANOG-dependent manner.

Suggested Citation

  • Yael Costa & Junjun Ding & Thorold W. Theunissen & Francesco Faiola & Timothy A. Hore & Pavel V. Shliaha & Miguel Fidalgo & Arven Saunders & Moyra Lawrence & Sabine Dietmann & Satyabrata Das & Dana N., 2013. "NANOG-dependent function of TET1 and TET2 in establishment of pluripotency," Nature, Nature, vol. 495(7441), pages 370-374, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7441:d:10.1038_nature11925
    DOI: 10.1038/nature11925
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11925
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11925?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Timothy D. Arthur & Jennifer P. Nguyen & Agnieszka D’Antonio-Chronowska & Hiroko Matsui & Nayara S. Silva & Isaac N. Joshua & André D. Luchessi & William W. Young Greenwald & Matteo D’Antonio & Martin, 2024. "Complex regulatory networks influence pluripotent cell state transitions in human iPSCs," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Javier Rodríguez-Ubreva & Anna Arutyunyan & Marc Jan Bonder & Lucía Del Pino-Molina & Stephen J. Clark & Carlos de la Calle-Fabregat & Luz Garcia-Alonso & Louis-François Handfield & Laura Ciudad & Edu, 2022. "Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Tao Huang & Dong Liu & Xiaomin Wang & Junqi Kuang & Manqi Wu & Beibei Wang & Zechuan Liang & Yixin Fan & Bo Chen & Zhaoyi Ma & Yu Fu & Wenhui Zhang & Jin Ming & Yue Qin & Chengchen Zhao & Bo Wang & Du, 2024. "Engineering mouse cell fate controller by rational design," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:495:y:2013:i:7441:d:10.1038_nature11925. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.