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USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110

Author

Listed:
  • Ji Li

    (Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA)

  • Vincenzo D’Angiolella

    (Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA
    Present address: Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.)

  • E. Scott Seeley

    (University of California San Francisco)

  • Sehyun Kim

    (Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA)

  • Tetsuo Kobayashi

    (Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA)

  • Wenxiang Fu

    (Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA)

  • Eric I. Campos

    (Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA)

  • Michele Pagano

    (Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA
    Howard Hughes Medical Institute, Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA)

  • Brian David Dynlacht

    (Smilow Research Center, New York University School of Medicine, 522 1st Avenue, New York, New York 10016, USA)

Abstract

Maintenance of normal levels of CP110 is essential to prevent over-duplication of centrosomes and genome instability; here, a deubiquitinating enzyme, USP33, is shown to stabilize CP110.

Suggested Citation

  • Ji Li & Vincenzo D’Angiolella & E. Scott Seeley & Sehyun Kim & Tetsuo Kobayashi & Wenxiang Fu & Eric I. Campos & Michele Pagano & Brian David Dynlacht, 2013. "USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110," Nature, Nature, vol. 495(7440), pages 255-259, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7440:d:10.1038_nature11941
    DOI: 10.1038/nature11941
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    Cited by:

    1. Yaping Huang & Changzheng Lu & Hanzhi Wang & Liya Gu & Yang-Xin Fu & Guo-Min Li, 2023. "DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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