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CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes

Author

Listed:
  • Akiyuki Taruno

    (University of Pennsylvania)

  • Valérie Vingtdeux

    (Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for Medical Research)

  • Makoto Ohmoto

    (Monell Chemical Senses Center)

  • Zhongming Ma

    (University of Pennsylvania)

  • Gennady Dvoryanchikov

    (Miller School of Medicine, University of Miami)

  • Ang Li

    (University of Pennsylvania
    Present address: Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.)

  • Leslie Adrien

    (Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for Medical Research)

  • Haitian Zhao

    (Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for Medical Research)

  • Sze Leung

    (Medical School, University of Minnesota Duluth)

  • Maria Abernethy

    (Medical School, University of Minnesota Duluth)

  • Jeremy Koppel

    (Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for Medical Research)

  • Peter Davies

    (Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for Medical Research
    Albert Einstein College of Medicine)

  • Mortimer M. Civan

    (University of Pennsylvania
    University of Pennsylvania)

  • Nirupa Chaudhari

    (Miller School of Medicine, University of Miami
    Program in Neurosciences, Miller School of Medicine, University of Miami)

  • Ichiro Matsumoto

    (Monell Chemical Senses Center)

  • Göran Hellekant

    (Medical School, University of Minnesota Duluth)

  • Michael G. Tordoff

    (Monell Chemical Senses Center)

  • Philippe Marambaud

    (Litwin-Zucker Research Center for the Study of Alzheimer’s Disease, The Feinstein Institute for Medical Research)

  • J. Kevin Foskett

    (University of Pennsylvania
    University of Pennsylvania)

Abstract

The voltage-gated ion channel CALHM1 is vital to taste-stimuli-evoked ATP release from sweet-, bitter- and umami-sensing taste bud cells in mice, but does not seem relevant to the recognition of sour and salty tastes.

Suggested Citation

  • Akiyuki Taruno & Valérie Vingtdeux & Makoto Ohmoto & Zhongming Ma & Gennady Dvoryanchikov & Ang Li & Leslie Adrien & Haitian Zhao & Sze Leung & Maria Abernethy & Jeremy Koppel & Peter Davies & Mortime, 2013. "CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes," Nature, Nature, vol. 495(7440), pages 223-226, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7440:d:10.1038_nature11906
    DOI: 10.1038/nature11906
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    Cited by:

    1. Johanna L. Syrjänen & Max Epstein & Ricardo Gómez & Hiro Furukawa, 2023. "Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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