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MicroRNA-34a regulates cardiac ageing and function

Author

Listed:
  • Reinier A. Boon

    (Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany)

  • Kazuma Iekushi

    (Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany)

  • Stefanie Lechner

    (Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-Universität München, 80337 Munich, Germany)

  • Timon Seeger

    (Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Internal Medicine III, Goethe University, 60590 Frankfurt, Germany)

  • Ariane Fischer

    (Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany)

  • Susanne Heydt

    (Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany)

  • David Kaluza

    (Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany)

  • Karine Tréguer

    (Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany)

  • Guillaume Carmona

    (Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany)

  • Angelika Bonauer

    (Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany)

  • Anton J. G. Horrevoets

    (VU University Medical Center, 1081BT Amsterdam, the Netherlands)

  • Nathalie Didier

    (Myology Group, UMR S787 INSERM, Université Pierre et Marie Curie Paris VI, Institut de Myologie, Pitie-Salpétrière, Paris Cedex, France)

  • Zenawit Girmatsion

    (Internal Medicine III, Goethe University, 60590 Frankfurt, Germany)

  • Peter Biliczki

    (Internal Medicine III, Goethe University, 60590 Frankfurt, Germany)

  • Joachim R. Ehrlich

    (Internal Medicine III, Goethe University, 60590 Frankfurt, Germany)

  • Hugo A. Katus

    (Internal Medicine III, Heidelberg Universiy Hospital, 69120 Heidelberg, Germany
    German Center for Cardiovascular Research DZHK, 13347 Berlin, Germany)

  • Oliver J. Müller

    (Internal Medicine III, Heidelberg Universiy Hospital, 69120 Heidelberg, Germany
    German Center for Cardiovascular Research DZHK, 13347 Berlin, Germany)

  • Michael Potente

    (Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
    Internal Medicine III, Goethe University, 60590 Frankfurt, Germany
    Present address: Max-Planck-Institute for Heart and Lung Reseach, 61231 Bad Nauheim, Germany.)

  • Andreas M. Zeiher

    (Internal Medicine III, Goethe University, 60590 Frankfurt, Germany
    German Center for Cardiovascular Research DZHK, 13347 Berlin, Germany)

  • Heiko Hermeking

    (Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-Universität München, 80337 Munich, Germany)

  • Stefanie Dimmeler

    (Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany
    German Center for Cardiovascular Research DZHK, 13347 Berlin, Germany)

Abstract

A role is demonstrated for miR-34a, a microRNA that is upregulated in the ageing heart; miR-34a downregulates PNUTS, a protein that protects cardiomyocytes and telomeres, silencing of miR-34a is therefore a promising therapeutic target.

Suggested Citation

  • Reinier A. Boon & Kazuma Iekushi & Stefanie Lechner & Timon Seeger & Ariane Fischer & Susanne Heydt & David Kaluza & Karine Tréguer & Guillaume Carmona & Angelika Bonauer & Anton J. G. Horrevoets & Na, 2013. "MicroRNA-34a regulates cardiac ageing and function," Nature, Nature, vol. 495(7439), pages 107-110, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7439:d:10.1038_nature11919
    DOI: 10.1038/nature11919
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