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‘See-saw’ expression of microRNA-198 and FSTL1 from a single transcript in wound healing

Author

Listed:
  • Gopinath M. Sundaram

    (Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore)

  • John E. A. Common

    (Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore)

  • Felicia E. Gopal

    (Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore)

  • Satyanarayana Srikanta

    (Jnana Sanjeevini Diabetes Center, Bangalore 560078, India)

  • Krishnaswamy Lakshman

    (Jnana Sanjeevini Diabetes Center, Bangalore 560078, India)

  • Declan P. Lunny

    (Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore)

  • Thiam C. Lim

    (Reconstructive & Aesthetic Surgery, National University Health System, 119074, Singapore
    Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore)

  • Vivek Tanavde

    (Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore
    Bioinformatics Institute, Agency for Science Technology & Research (A*STAR), 138671, Singapore)

  • E. Birgitte Lane

    (Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore
    Yong Loo Lin School of Medicine, National University of Singapore, 119074, Singapore
    Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore)

  • Prabha Sampath

    (Institute of Medical Biology, Agency for Science Technology & Research (A*STAR), 138648, Singapore
    Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore)

Abstract

A post-transcriptional switch that controls spatiotemporal and mutually exclusive expression of two alternative gene products from a single transcript is reported; these gene products—miR-198 and FSTL1—are found to have opposing functions on keratinocyte migration and wound healing.

Suggested Citation

  • Gopinath M. Sundaram & John E. A. Common & Felicia E. Gopal & Satyanarayana Srikanta & Krishnaswamy Lakshman & Declan P. Lunny & Thiam C. Lim & Vivek Tanavde & E. Birgitte Lane & Prabha Sampath, 2013. "‘See-saw’ expression of microRNA-198 and FSTL1 from a single transcript in wound healing," Nature, Nature, vol. 495(7439), pages 103-106, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7439:d:10.1038_nature11890
    DOI: 10.1038/nature11890
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