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High salt recruits aversive taste pathways

Author

Listed:
  • Yuki Oka

    (Columbia College of Physicians and Surgeons, Columbia University)

  • Matthew Butnaru

    (Columbia College of Physicians and Surgeons, Columbia University)

  • Lars von Buchholtz

    (National Institute of Dental and Craniofacial Research, National Institutes of Health)

  • Nicholas J. P. Ryba

    (National Institute of Dental and Craniofacial Research, National Institutes of Health)

  • Charles S. Zuker

    (Columbia College of Physicians and Surgeons, Columbia University)

Abstract

High concentrations of salt activate sour- and bitter-taste-sensing cells in the tongues of mice, and genetic silencing of these pathways abolishes behavioural aversion to concentrated salt; this ‘co-opting’ of the two primary aversive taste pathways (sour and bitter) may have evolved so that high salt levels reliably trigger behavioural rejection.

Suggested Citation

  • Yuki Oka & Matthew Butnaru & Lars von Buchholtz & Nicholas J. P. Ryba & Charles S. Zuker, 2013. "High salt recruits aversive taste pathways," Nature, Nature, vol. 494(7438), pages 472-475, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7438:d:10.1038_nature11905
    DOI: 10.1038/nature11905
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    Cited by:

    1. Shobha Mummalaneni & Jie Qian & Tam-Hao T Phan & Mee-Ra Rhyu & Gerard L Heck & John A DeSimone & Vijay Lyall, 2014. "Effect of ENaC Modulators on Rat Neural Responses to NaCl," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-18, May.
    2. Ziyu Liang & Courtney E. Wilson & Bochuan Teng & Sue C. Kinnamon & Emily R. Liman, 2023. "The proton channel OTOP1 is a sensor for the taste of ammonium chloride," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Ashkan A. Shahbandi & Ezen Choo & Robin Dando, 2018. "Receptor Regulation in Taste: Can Diet Influence How We Perceive Foods?," J, MDPI, vol. 1(1), pages 1-10, October.
    4. Sze-Yen Tan & Paridhi Tuli & Giecella Thio & Breannah Noel & Bailey Marshall & Zhen Yu & Rachael Torelli & Sarah Fitzgerald & Maria Chan & Robin M. Tucker, 2022. "A Systematic Review of Salt Taste Function and Perception Impairments in Adults with Chronic Kidney Disease," IJERPH, MDPI, vol. 19(19), pages 1-19, October.

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