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Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

Author

Listed:
  • Fan Lai

    (The Wistar Institute, 3601 Spruce Street)

  • Ulf A. Orom

    (Max Planck Institute for Molecular Genetics, Ihnestr, 14195 Berlin, Germany)

  • Matteo Cesaroni

    (The Wistar Institute, 3601 Spruce Street)

  • Malte Beringer

    (Center de Regulacio Genomica and UPF, Barcelona 08003, Spain)

  • Dylan J. Taatjes

    (University of Colorado, 215 UCB, Boulder, Colorado 80309, USA)

  • Gerd A. Blobel

    (The Children’s Hospital of Philadelphia)

  • Ramin Shiekhattar

    (The Wistar Institute, 3601 Spruce Street)

Abstract

A class of long non-coding RNA (lncRNA) with enhancer-like activity is found to associate with the co-activator complex Mediator and promote its genomic association and enzymatic activity; together with Mediator, the lncRNAs also help to maintain the chromosomal architecture of active regulatory elements.

Suggested Citation

  • Fan Lai & Ulf A. Orom & Matteo Cesaroni & Malte Beringer & Dylan J. Taatjes & Gerd A. Blobel & Ramin Shiekhattar, 2013. "Activating RNAs associate with Mediator to enhance chromatin architecture and transcription," Nature, Nature, vol. 494(7438), pages 497-501, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7438:d:10.1038_nature11884
    DOI: 10.1038/nature11884
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