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A two-step mechanism for TRF2-mediated chromosome-end protection

Author

Listed:
  • Keiji Okamoto

    (Laboratory of Chromosome Biology and Genomic Stability, The Scripps Research Institute)

  • Cristina Bartocci

    (Laboratory of Chromosome Biology and Genomic Stability, The Scripps Research Institute)

  • Iliana Ouzounov

    (Laboratory of Chromosome Biology and Genomic Stability, The Scripps Research Institute)

  • Jolene K. Diedrich

    (The Scripps Research Institute)

  • John R. Yates III

    (The Scripps Research Institute)

  • Eros Lazzerini Denchi

    (Laboratory of Chromosome Biology and Genomic Stability, The Scripps Research Institute)

Abstract

The telomere-biding protein TRF2 is shown to protect telomeres from activating the DNA-damage response through two mechanisms: preventing the activation ATM kinase through its dimerization domain, in addition to independently suppressing signalling events occurring downstream of ATM.

Suggested Citation

  • Keiji Okamoto & Cristina Bartocci & Iliana Ouzounov & Jolene K. Diedrich & John R. Yates III & Eros Lazzerini Denchi, 2013. "A two-step mechanism for TRF2-mediated chromosome-end protection," Nature, Nature, vol. 494(7438), pages 502-505, February.
  • Handle: RePEc:nat:nature:v:494:y:2013:i:7438:d:10.1038_nature11873
    DOI: 10.1038/nature11873
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