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APOBEC3B is an enzymatic source of mutation in breast cancer

Author

Listed:
  • Michael B. Burns

    (Biochemistry, University of Minnesota
    Masonic Cancer Center, University of Minnesota
    Institute for Molecular Virology, University of Minnesota
    Center for Genome Engineering, University of Minnesota)

  • Lela Lackey

    (Biochemistry, University of Minnesota
    Masonic Cancer Center, University of Minnesota
    Institute for Molecular Virology, University of Minnesota
    Center for Genome Engineering, University of Minnesota)

  • Michael A. Carpenter

    (Biochemistry, University of Minnesota
    Masonic Cancer Center, University of Minnesota
    Institute for Molecular Virology, University of Minnesota
    Center for Genome Engineering, University of Minnesota)

  • Anurag Rathore

    (Biochemistry, University of Minnesota
    Masonic Cancer Center, University of Minnesota
    Institute for Molecular Virology, University of Minnesota
    Center for Genome Engineering, University of Minnesota)

  • Allison M. Land

    (Biochemistry, University of Minnesota
    Masonic Cancer Center, University of Minnesota
    Institute for Molecular Virology, University of Minnesota
    Center for Genome Engineering, University of Minnesota)

  • Brandon Leonard

    (Masonic Cancer Center, University of Minnesota
    Institute for Molecular Virology, University of Minnesota
    Center for Genome Engineering, University of Minnesota
    Microbiology, Cancer Biology and Immunology Graduate Program, University of Minnesota)

  • Eric W. Refsland

    (Biochemistry, University of Minnesota
    Masonic Cancer Center, University of Minnesota
    Institute for Molecular Virology, University of Minnesota
    Center for Genome Engineering, University of Minnesota)

  • Delshanee Kotandeniya

    (Masonic Cancer Center, University of Minnesota
    University of Minnesota)

  • Natalia Tretyakova

    (Masonic Cancer Center, University of Minnesota
    University of Minnesota)

  • Jason B. Nikas

    (Masonic Cancer Center, University of Minnesota)

  • Douglas Yee

    (Masonic Cancer Center, University of Minnesota)

  • Nuri A. Temiz

    (In Silico Research Centers of Excellence, Advanced Biomedical Computing Center, Information Systems Program, SAIC-Frederick Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA)

  • Duncan E. Donohue

    (In Silico Research Centers of Excellence, Advanced Biomedical Computing Center, Information Systems Program, SAIC-Frederick Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA)

  • Rebecca M. McDougle

    (Biochemistry, University of Minnesota
    Masonic Cancer Center, University of Minnesota
    Institute for Molecular Virology, University of Minnesota
    Center for Genome Engineering, University of Minnesota)

  • William L. Brown

    (Biochemistry, University of Minnesota
    Masonic Cancer Center, University of Minnesota
    Institute for Molecular Virology, University of Minnesota
    Center for Genome Engineering, University of Minnesota)

  • Emily K. Law

    (Biochemistry, University of Minnesota
    Masonic Cancer Center, University of Minnesota
    Institute for Molecular Virology, University of Minnesota
    Center for Genome Engineering, University of Minnesota)

  • Reuben S. Harris

    (Biochemistry, University of Minnesota
    Masonic Cancer Center, University of Minnesota
    Institute for Molecular Virology, University of Minnesota
    Center for Genome Engineering, University of Minnesota)

Abstract

The DNA cytosine deaminase APOBEC3B is shown to be overexpressed and highly active in most breast cancers; deamination by APOBEC3B could serve as an endogenous, continual source of DNA damage leading to mutations, including C-to-T transitions and other aberrations seen in many breast tumours.

Suggested Citation

  • Michael B. Burns & Lela Lackey & Michael A. Carpenter & Anurag Rathore & Allison M. Land & Brandon Leonard & Eric W. Refsland & Delshanee Kotandeniya & Natalia Tretyakova & Jason B. Nikas & Douglas Ye, 2013. "APOBEC3B is an enzymatic source of mutation in breast cancer," Nature, Nature, vol. 494(7437), pages 366-370, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7437:d:10.1038_nature11881
    DOI: 10.1038/nature11881
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    Citations

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    Cited by:

    1. Atanu Maiti & Adam K. Hedger & Wazo Myint & Vanivilasini Balachandran & Jonathan K. Watts & Celia A. Schiffer & Hiroshi Matsuo, 2022. "Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Stefan Harjes & Harikrishnan M. Kurup & Amanda E. Rieffer & Maitsetseg Bayarjargal & Jana Filitcheva & Yongdong Su & Tracy K. Hale & Vyacheslav V. Filichev & Elena Harjes & Reuben S. Harris & Geoffrey, 2023. "Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Eriko Tokunaga & Nami Yamashita & Kimihiro Tanaka & Yuka Inoue & Sayuri Akiyoshi & Hiroshi Saeki & Eiji Oki & Hiroyuki Kitao & Yoshihiko Maehara, 2016. "Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-11, December.
    4. Yasha Butt & Ramin Sakhtemani & Rukshana Mohamad-Ramshan & Michael S. Lawrence & Ashok S. Bhagwat, 2024. "Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Ambrocio Sanchez & Pedro Ortega & Ramin Sakhtemani & Lavanya Manjunath & Sunwoo Oh & Elodie Bournique & Alexandrea Becker & Kyumin Kim & Cameron Durfee & Nuri Alpay Temiz & Xiaojiang S. Chen & Reuben , 2024. "Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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