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OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3

Author

Listed:
  • Hongbo Hu

    (The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA)

  • George C. Brittain

    (The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA)

  • Jae-Hoon Chang

    (The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA)

  • Nahum Puebla-Osorio

    (The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA)

  • Jin Jin

    (The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA)

  • Anna Zal

    (The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA)

  • Yichuan Xiao

    (The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA)

  • Xuhong Cheng

    (The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA)

  • Mikyoung Chang

    (The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA)

  • Yang-Xin Fu

    (University of Chicago)

  • Tomasz Zal

    (The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA
    The University of Texas Graduate School of Biomedical Sciences)

  • Chengming Zhu

    (The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA
    The University of Texas Graduate School of Biomedical Sciences)

  • Shao-Cong Sun

    (The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, USA
    The University of Texas Graduate School of Biomedical Sciences)

Abstract

The deubiquitinase OTUD7B is shown to regulate the non-canonical NF-κB pathway by inhibiting TRAF3 proteolysis.

Suggested Citation

  • Hongbo Hu & George C. Brittain & Jae-Hoon Chang & Nahum Puebla-Osorio & Jin Jin & Anna Zal & Yichuan Xiao & Xuhong Cheng & Mikyoung Chang & Yang-Xin Fu & Tomasz Zal & Chengming Zhu & Shao-Cong Sun, 2013. "OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3," Nature, Nature, vol. 494(7437), pages 371-374, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7437:d:10.1038_nature11831
    DOI: 10.1038/nature11831
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