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T-helper-1-cell cytokines drive cancer into senescence

Author

Listed:
  • Heidi Braumüller

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Thomas Wieder

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Ellen Brenner

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Sonja Aßmann

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Matthias Hahn

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Mohammed Alkhaled

    (Oncology/Hematology, Eberhard Karls University, Hoppe-Seyler-Strasse 1, 72076 Tübingen, Germany)

  • Karin Schilbach

    (Oncology/Hematology, Eberhard Karls University, Hoppe-Seyler-Strasse 1, 72076 Tübingen, Germany)

  • Frank Essmann

    (Interfaculty Institute for Biochemistry, Eberhard Karls University, Hoppe-Seyler-Strasse 4, 72076 Tübingen, Germany)

  • Manfred Kneilling

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Christoph Griessinger

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
    Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, Eberhard Karls University, Röntgenweg 13, 72076 Tübingen, Germany)

  • Felicia Ranta

    (Endocrinology, Diabetology and Clinical Chemistry, Eberhard Karls University, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany)

  • Susanne Ullrich

    (Endocrinology, Diabetology and Clinical Chemistry, Eberhard Karls University, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany)

  • Ralph Mocikat

    (Institut für Molekulare Immunologie, Helmholtz-Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Marchionini Strasse 25, 81377 München, Germany)

  • Kilian Braungart

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Tarun Mehra

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Birgit Fehrenbacher

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Julia Berdel

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Heike Niessner

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Friedegund Meier

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Maries van den Broek

    (Clinic of Oncology, University Hospital Zurich, Raemistrasse 100, 8091 Zürich, Switzerland)

  • Hans-Ulrich Häring

    (Endocrinology, Diabetology and Clinical Chemistry, Eberhard Karls University, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany)

  • Rupert Handgretinger

    (Oncology/Hematology, Eberhard Karls University, Hoppe-Seyler-Strasse 1, 72076 Tübingen, Germany
    Comprehensive Cancer Center Tübingen, German Cancer Consortium (DKTK), Herrenberger Strasse 23, D-72070 Tübingen, Germany)

  • Leticia Quintanilla-Martinez

    (Eberhard Karls University, Liebermeister Strasse 8, 72076 Tübingen, Germany)

  • Falko Fend

    (Comprehensive Cancer Center Tübingen, German Cancer Consortium (DKTK), Herrenberger Strasse 23, D-72070 Tübingen, Germany
    Eberhard Karls University, Liebermeister Strasse 8, 72076 Tübingen, Germany)

  • Marina Pesic

    (Eberhard Karls University, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany)

  • Jürgen Bauer

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Lars Zender

    (Eberhard Karls University, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany)

  • Martin Schaller

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany)

  • Klaus Schulze-Osthoff

    (Interfaculty Institute for Biochemistry, Eberhard Karls University, Hoppe-Seyler-Strasse 4, 72076 Tübingen, Germany
    Comprehensive Cancer Center Tübingen, German Cancer Consortium (DKTK), Herrenberger Strasse 23, D-72070 Tübingen, Germany)

  • Martin Röcken

    (Eberhard Karls University, Liebermeister Strasse 25, 72076 Tübingen, Germany
    Comprehensive Cancer Center Tübingen, German Cancer Consortium (DKTK), Herrenberger Strasse 23, D-72070 Tübingen, Germany)

Abstract

T-helper-1-cell cytokines tumour necrosis factor and interferon-γ are shown to drive tumour cells into senescence in a mouse model of β-cell carcinoma and human carcinoma cells.

Suggested Citation

  • Heidi Braumüller & Thomas Wieder & Ellen Brenner & Sonja Aßmann & Matthias Hahn & Mohammed Alkhaled & Karin Schilbach & Frank Essmann & Manfred Kneilling & Christoph Griessinger & Felicia Ranta & Susa, 2013. "T-helper-1-cell cytokines drive cancer into senescence," Nature, Nature, vol. 494(7437), pages 361-365, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7437:d:10.1038_nature11824
    DOI: 10.1038/nature11824
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    Cited by:

    1. Awatef Allouch & Laurent Voisin & Yanyan Zhang & Syed Qasim Raza & Yann Lecluse & Julien Calvo & Dorothée Selimoglu-Buet & Stéphane Botton & Fawzia Louache & Françoise Pflumio & Eric Solary & Jean-Luc, 2022. "CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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