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A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis

Author

Listed:
  • Paola Picotti

    (Institute of Molecular Systems Biology, ETH Zurich, Zurich CH-8093, Switzerland
    Institute of Biochemistry, ETH Zurich, Zurich CH-8093, Switzerland)

  • Mathieu Clément-Ziza

    (Biotechnology Centre, Technische Universitaet Dresden, D-01069 Dresden, Germany)

  • Henry Lam

    (The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong)

  • David S. Campbell

    (Institute for Systems Biology)

  • Alexander Schmidt

    (Proteomics Core Facility Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland)

  • Eric W. Deutsch

    (Institute for Systems Biology)

  • Hannes Röst

    (Institute of Molecular Systems Biology, ETH Zurich, Zurich CH-8093, Switzerland)

  • Zhi Sun

    (Institute for Systems Biology)

  • Oliver Rinner

    (Institute of Molecular Systems Biology, ETH Zurich, Zurich CH-8093, Switzerland
    Biognosys AG, Zurich CH-8093, Switzerland)

  • Lukas Reiter

    (Institute of Molecular Systems Biology, ETH Zurich, Zurich CH-8093, Switzerland
    Biognosys AG, Zurich CH-8093, Switzerland)

  • Qin Shen

    (Institute of Molecular Systems Biology, ETH Zurich, Zurich CH-8093, Switzerland
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Jacob J. Michaelson

    (Biotechnology Centre, Technische Universitaet Dresden, D-01069 Dresden, Germany)

  • Andreas Frei

    (Institute of Molecular Systems Biology, ETH Zurich, Zurich CH-8093, Switzerland)

  • Simon Alberti

    (Max Planck Institute of Molecular Cell Biology and Genetics, D-01307 Dresden, Germany)

  • Ulrike Kusebauch

    (Institute for Systems Biology)

  • Bernd Wollscheid

    (Institute of Molecular Systems Biology, ETH Zurich, Zurich CH-8093, Switzerland)

  • Robert L. Moritz

    (Institute for Systems Biology)

  • Andreas Beyer

    (Biotechnology Centre, Technische Universitaet Dresden, D-01069 Dresden, Germany)

  • Ruedi Aebersold

    (Institute of Molecular Systems Biology, ETH Zurich, Zurich CH-8093, Switzerland
    Competence Center for Systems Physiology and Metabolic Diseases, Zurich CH-8093, Switzerland
    Faculty of Science, University of Zurich, Zurich CH-8057, Switzerland)

Abstract

High-throughput peptide synthesis and mass spectrometry are used to generate a near-complete reference map of the Saccharomyces cerevisiae proteome; two versions of the map (supporting discovery- and hypothesis-driven proteomics) are then applied to a protein-based quantitative trait locus analysis.

Suggested Citation

  • Paola Picotti & Mathieu Clément-Ziza & Henry Lam & David S. Campbell & Alexander Schmidt & Eric W. Deutsch & Hannes Röst & Zhi Sun & Oliver Rinner & Lukas Reiter & Qin Shen & Jacob J. Michaelson & And, 2013. "A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis," Nature, Nature, vol. 494(7436), pages 266-270, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7436:d:10.1038_nature11835
    DOI: 10.1038/nature11835
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