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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Author

Listed:
  • Meritxell Huch

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht)

  • Craig Dorrell

    (Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University)

  • Sylvia F. Boj

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht)

  • Johan H. van Es

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht)

  • Vivian S. W. Li

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht)

  • Marc van de Wetering

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht)

  • Toshiro Sato

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht
    Present address: Department of Gastroenterology, School of Medicine, Keio University, 35 Shinanomachi, Shinnjukuku, Tokyo, 160-8582, Japan.)

  • Karien Hamer

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht)

  • Nobuo Sasaki

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht)

  • Milton J. Finegold

    (Texas Children’s Hospital)

  • Annelise Haft

    (Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University)

  • Robert G. Vries

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht)

  • Markus Grompe

    (Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University)

  • Hans Clevers

    (Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht & University Medical Centre Utrecht)

Abstract

A mouse model of liver damage has identified a population of Lrg5+ liver stem cells that can generate hepatoctyes and bile ducts in vivo.

Suggested Citation

  • Meritxell Huch & Craig Dorrell & Sylvia F. Boj & Johan H. van Es & Vivian S. W. Li & Marc van de Wetering & Toshiro Sato & Karien Hamer & Nobuo Sasaki & Milton J. Finegold & Annelise Haft & Robert G. , 2013. "In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration," Nature, Nature, vol. 494(7436), pages 247-250, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7436:d:10.1038_nature11826
    DOI: 10.1038/nature11826
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    Cited by:

    1. Delilah Hendriks & Benedetta Artegiani & Thanasis Margaritis & Iris Zoutendijk & Susana Chuva de Sousa Lopes & Hans Clevers, 2024. "Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Suran Kim & Sungjin Min & Yi Sun Choi & Sung-Hyun Jo & Jae Hun Jung & Kyusun Han & Jin Kim & Soohwan An & Yong Woo Ji & Yun-Gon Kim & Seung-Woo Cho, 2022. "Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    3. Teresa L. Rapp & Cole A. DeForest, 2023. "Tricolor visible wavelength-selective photodegradable hydrogel biomaterials," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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