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A direct and melanopsin-dependent fetal light response regulates mouse eye development

Author

Listed:
  • Sujata Rao

    (The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center)

  • Christina Chun

    (University of California, San Francisco, San Francisco, California 94158, USA)

  • Jieqing Fan

    (The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center)

  • J. Matthew Kofron

    (Cincinnati Children’s Hospital Medical Center)

  • Michael B. Yang

    (The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center
    University of Cincinnati, College of Medicine)

  • Rashmi S. Hegde

    (Cincinnati Children’s Hospital Medical Center)

  • Napoleone Ferrara

    (Genentech Inc., 1 DNA Way)

  • David R. Copenhagen

    (University of California, San Francisco, San Francisco, California 94158, USA)

  • Richard A. Lang

    (The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center
    Cincinnati Children’s Hospital Medical Center
    University of Cincinnati, College of Medicine)

Abstract

During retinal vascular development there is simultaneous regression of the hyaloid vasculature and formation of the retinal vasculature; here it is demonstrated that regression of developing vasculature is light dependent and acts via the photoreceptor melanopsin.

Suggested Citation

  • Sujata Rao & Christina Chun & Jieqing Fan & J. Matthew Kofron & Michael B. Yang & Rashmi S. Hegde & Napoleone Ferrara & David R. Copenhagen & Richard A. Lang, 2013. "A direct and melanopsin-dependent fetal light response regulates mouse eye development," Nature, Nature, vol. 494(7436), pages 243-246, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7436:d:10.1038_nature11823
    DOI: 10.1038/nature11823
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