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Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

Author

Listed:
  • Meghna Das Thakur

    (Novartis Institutes for Biomedical Research)

  • Fernando Salangsang

    (Novartis Institutes for Biomedical Research)

  • Allison S. Landman

    (University of California San Francisco)

  • William R. Sellers

    (Novartis Institutes for Biomedical Research)

  • Nancy K. Pryer

    (Novartis Institutes for Biomedical Research)

  • Mitchell P. Levesque

    (University Hospital Zurich, Gloriastrasse 31, 8091 Zürich, Switzerland)

  • Reinhard Dummer

    (University Hospital Zurich, Gloriastrasse 31, 8091 Zürich, Switzerland)

  • Martin McMahon

    (University of California San Francisco)

  • Darrin D. Stuart

    (Novartis Institutes for Biomedical Research)

Abstract

BRAF inhibitors such as vemurafenib have shown promising effects in patients with BRAF-mutant melanomas, but the tumours generally develop resistance; vemurafenib-resistant melanomas are now shown to be drug dependent, and an intermittent dosing schedule can help prevent drug resistance.

Suggested Citation

  • Meghna Das Thakur & Fernando Salangsang & Allison S. Landman & William R. Sellers & Nancy K. Pryer & Mitchell P. Levesque & Reinhard Dummer & Martin McMahon & Darrin D. Stuart, 2013. "Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance," Nature, Nature, vol. 494(7436), pages 251-255, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7436:d:10.1038_nature11814
    DOI: 10.1038/nature11814
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    Cited by:

    1. Guillaume Harmange & Raúl A. Reyes Hueros & Dylan L. Schaff & Benjamin Emert & Michael Saint-Antoine & Laura C. Kim & Zijian Niu & Shivani Nellore & Mitchell E. Fane & Gretchen M. Alicea & Ashani T. W, 2023. "Disrupting cellular memory to overcome drug resistance," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Ruitong Li & Olaf Klingbeil & Davide Monducci & Michael J. Young & Diego J. Rodriguez & Zaid Bayyat & Joshua M. Dempster & Devishi Kesar & Xiaoping Yang & Mahdi Zamanighomi & Christopher R. Vakoc & Ta, 2022. "Comparative optimization of combinatorial CRISPR screens," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Benjamin Wölfl & Hedy te Rietmole & Monica Salvioli & Artem Kaznatcheev & Frank Thuijsman & Joel S. Brown & Boudewijn Burgering & Kateřina Staňková, 2022. "The Contribution of Evolutionary Game Theory to Understanding and Treating Cancer," Dynamic Games and Applications, Springer, vol. 12(2), pages 313-342, June.
    4. Claudia Capparelli & Timothy J. Purwin & McKenna Glasheen & Signe Caksa & Manoela Tiago & Nicole Wilski & Danielle Pomante & Sheera Rosenbaum & Mai Q. Nguyen & Weijia Cai & Janusz Franco-Barraza & Ric, 2022. "Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Maria Gonzalez-Cao & Clara Mayo de las Casas & Juana Oramas & Miguel A. Berciano-Guerrero & Luis Cruz & Pablo Cerezuela & Ana Arance & Eva Muñoz-Couselo & Enrique Espinosa & Teresa Puertolas & Roberto, 2021. "Intermittent BRAF inhibition in advanced BRAF mutated melanoma results of a phase II randomized trial," Nature Communications, Nature, vol. 12(1), pages 1-6, December.

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