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A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

Author

Listed:
  • Christoph S. N. Klose

    (Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany)

  • Elina A. Kiss

    (Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany)

  • Vera Schwierzeck

    (Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
    Centre of Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Breisacher Strasse 117, D-79106 Freiburg, Germany)

  • Karolina Ebert

    (Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
    University of Freiburg Medical Centre, Hugstetter Strasse 55, D-79106 Freiburg, Germany)

  • Thomas Hoyler

    (Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany)

  • Yannick d’Hargues

    (Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
    University of Freiburg Medical Centre, Hugstetter Strasse 55, D-79106 Freiburg, Germany)

  • Nathalie Göppert

    (Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany)

  • Andrew L. Croxford

    (Institute of Molecular Medicine, University of Mainz, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany
    Institute of Experimental Immunology, Neuroimmunology, University of Zürich, CH-8006 Zürich, Switzerland)

  • Ari Waisman

    (Institute of Molecular Medicine, University of Mainz, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany)

  • Yakup Tanriver

    (Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
    Centre of Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Breisacher Strasse 117, D-79106 Freiburg, Germany
    University of Freiburg Medical Centre, Hugstetter Strasse 55, D-79106 Freiburg, Germany)

  • Andreas Diefenbach

    (Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany
    Centre of Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Breisacher Strasse 117, D-79106 Freiburg, Germany
    Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Schänzlestrasse 18, D-79104 Freiburg, Germany)

Abstract

The graded expression of the transcription factor T-bet in CCR6−RORγt+ innate lymphoid cells is found to be involved in the control of interferon-γ expression, a cytokine that is required to protect the epithelial barrier against Salmonella infections.

Suggested Citation

  • Christoph S. N. Klose & Elina A. Kiss & Vera Schwierzeck & Karolina Ebert & Thomas Hoyler & Yannick d’Hargues & Nathalie Göppert & Andrew L. Croxford & Ari Waisman & Yakup Tanriver & Andreas Diefenbac, 2013. "A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells," Nature, Nature, vol. 494(7436), pages 261-265, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7436:d:10.1038_nature11813
    DOI: 10.1038/nature11813
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