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tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans

Author

Listed:
  • Marios Chatzigeorgiou

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Sangsu Bang

    (Korea University College of Medicine, Seoul 136-705, Korea)

  • Sun Wook Hwang

    (Korea University College of Medicine, Seoul 136-705, Korea)

  • William R. Schafer

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

Abstract

The membrane protein TMC-1 is required for salt avoidance behaviour in C. elegans, functions as an ion channel directly activated by NaCl in vitro and is a candidate salt chemosensor; the human homologue of TMC-1 is linked to deafness and may be the cochlear hair-cell mechanotransduction channel.

Suggested Citation

  • Marios Chatzigeorgiou & Sangsu Bang & Sun Wook Hwang & William R. Schafer, 2013. "tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans," Nature, Nature, vol. 494(7435), pages 95-99, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7435:d:10.1038_nature11845
    DOI: 10.1038/nature11845
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    Cited by:

    1. Martina Nicoletti & Letizia Chiodo & Alessandro Loppini, 2021. "Biophysics and Modeling of Mechanotransduction in Neurons: A Review," Mathematics, MDPI, vol. 9(4), pages 1-32, February.
    2. Hagar Setty & Yehuda Salzberg & Shadi Karimi & Elisheva Berent-Barzel & Michael Krieg & Meital Oren-Suissa, 2022. "Sexually dimorphic architecture and function of a mechanosensory circuit in C. elegans," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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