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Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells

Author

Listed:
  • Gretchen E. Diehl

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA)

  • Randy S. Longman

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Columbia University, New York, New York 10032, USA)

  • Jing-Xin Zhang

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Present addresses: Sanofi Oncology, Cambridge, Massachusetts 02139, USA (J.-X.Z.); Dynamics of Immune Responses, Institut Pasteur, 75015 Paris, France, and Institut National de la Santé et de la Recherche Médicale U668, Equipe Avenir, 75015 Paris, France (B.B.).)

  • Beatrice Breart

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Present addresses: Sanofi Oncology, Cambridge, Massachusetts 02139, USA (J.-X.Z.); Dynamics of Immune Responses, Institut Pasteur, 75015 Paris, France, and Institut National de la Santé et de la Recherche Médicale U668, Equipe Avenir, 75015 Paris, France (B.B.).)

  • Carolina Galan

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA)

  • Adolfo Cuesta

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016, USA)

  • Susan R. Schwab

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA)

  • Dan R. Littman

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016, USA)

Abstract

In mice, commensal bacteria are shown to provide critical signals that limit bacterial trafficking to the mesenteric lymph nodes by immune cells, thus preventing the induction of mucosal immune responses.

Suggested Citation

  • Gretchen E. Diehl & Randy S. Longman & Jing-Xin Zhang & Beatrice Breart & Carolina Galan & Adolfo Cuesta & Susan R. Schwab & Dan R. Littman, 2013. "Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells," Nature, Nature, vol. 494(7435), pages 116-120, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7435:d:10.1038_nature11809
    DOI: 10.1038/nature11809
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