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Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells

Author

Listed:
  • Ryoko Araki

    (Transcriptome Research Group, National Institute of Radiological Sciences
    PRESTO, Japan Science and Technology Agency (JST))

  • Masahiro Uda

    (Transcriptome Research Group, National Institute of Radiological Sciences)

  • Yuko Hoki

    (Transcriptome Research Group, National Institute of Radiological Sciences)

  • Misato Sunayama

    (Transcriptome Research Group, National Institute of Radiological Sciences)

  • Miki Nakamura

    (Transcriptome Research Group, National Institute of Radiological Sciences)

  • Shunsuke Ando

    (Transcriptome Research Group, National Institute of Radiological Sciences)

  • Mayumi Sugiura

    (Transcriptome Research Group, National Institute of Radiological Sciences)

  • Hisashi Ideno

    (Transcriptome Research Group, National Institute of Radiological Sciences
    School of Dental Medicine, Tsurumi University)

  • Akemi Shimada

    (School of Dental Medicine, Tsurumi University)

  • Akira Nifuji

    (Transcriptome Research Group, National Institute of Radiological Sciences
    School of Dental Medicine, Tsurumi University)

  • Masumi Abe

    (Transcriptome Research Group, National Institute of Radiological Sciences)

Abstract

Immune rejection may limit the therapeutic use of induced pluripotent stem cells (iPSCs); here, terminally differentiated mouse iPSCs are shown to generate negligible immune rejection in their host.

Suggested Citation

  • Ryoko Araki & Masahiro Uda & Yuko Hoki & Misato Sunayama & Miki Nakamura & Shunsuke Ando & Mayumi Sugiura & Hisashi Ideno & Akemi Shimada & Akira Nifuji & Masumi Abe, 2013. "Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells," Nature, Nature, vol. 494(7435), pages 100-104, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7435:d:10.1038_nature11807
    DOI: 10.1038/nature11807
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