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Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs

Author

Listed:
  • Changsung Kim

    (Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute)

  • Johnson Wong

    (Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute)

  • Jianyan Wen

    (Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute
    China-Japan Friendship Hospital)

  • Shirong Wang

    (Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute)

  • Cheng Wang

    (Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute)

  • Sean Spiering

    (Muscle Regeneration and Development Program, Sanford-Burnham Medical Research Institute)

  • Natalia G. Kan

    (Muscle Regeneration and Development Program, Sanford-Burnham Medical Research Institute)

  • Sonia Forcales

    (Muscle Regeneration and Development Program, Sanford-Burnham Medical Research Institute)

  • Pier Lorenzo Puri

    (Muscle Regeneration and Development Program, Sanford-Burnham Medical Research Institute
    Dulbecco Telethon Institute, IRCCS Fondazione Santa Lucia, 00179 Rome, Italy)

  • Teresa C. Leone

    (Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute)

  • Joseph E. Marine

    (Johns Hopkins University School of Medicine)

  • Hugh Calkins

    (Johns Hopkins University School of Medicine)

  • Daniel P. Kelly

    (Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute)

  • Daniel P. Judge

    (Johns Hopkins University School of Medicine)

  • Huei-Sheng Vincent Chen

    (Del E. Webb Neuroscience, Aging & Stem Cell Research Center, Sanford-Burnham Medical Research Institute
    University of California-San Diego)

Abstract

This study demonstrates that an inheritable adult onset heart disease can be modelled in vitro within months with the help of metabolic maturation induction.

Suggested Citation

  • Changsung Kim & Johnson Wong & Jianyan Wen & Shirong Wang & Cheng Wang & Sean Spiering & Natalia G. Kan & Sonia Forcales & Pier Lorenzo Puri & Teresa C. Leone & Joseph E. Marine & Hugh Calkins & Danie, 2013. "Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs," Nature, Nature, vol. 494(7435), pages 105-110, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7435:d:10.1038_nature11799
    DOI: 10.1038/nature11799
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    Cited by:

    1. Aina Lluch & Jessica Latorre & Angela Serena-Maione & Isabel Espadas & Estefanía Caballano-Infantes & José M. Moreno-Navarrete & Núria Oliveras-Cañellas & Wifredo Ricart & María M. Malagón & Alejandro, 2023. "Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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