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The architecture of human general transcription factor TFIID core complex

Author

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  • Christoph Bieniossek

    (European Molecular Biology Laboratory (EMBL) Grenoble Outstation, and Unit of Virus Host Cell Interactions UVHCI, UJF-CNRS-EMBL Unité Mixte International UMI 3265, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9, France)

  • Gabor Papai

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 1 rue Laurent Fries, BP10142, 67404 Illkirch, and U964 Inserm F-67400, and UMR7104 CNRS Illkirch, and Université de Strasbourg)

  • Christiane Schaffitzel

    (European Molecular Biology Laboratory (EMBL) Grenoble Outstation, and Unit of Virus Host Cell Interactions UVHCI, UJF-CNRS-EMBL Unité Mixte International UMI 3265, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9, France)

  • Frederic Garzoni

    (European Molecular Biology Laboratory (EMBL) Grenoble Outstation, and Unit of Virus Host Cell Interactions UVHCI, UJF-CNRS-EMBL Unité Mixte International UMI 3265, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9, France)

  • Maxime Chaillet

    (European Molecular Biology Laboratory (EMBL) Grenoble Outstation, and Unit of Virus Host Cell Interactions UVHCI, UJF-CNRS-EMBL Unité Mixte International UMI 3265, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9, France)

  • Elisabeth Scheer

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 1 rue Laurent Fries, BP10142, 67404 Illkirch, and U964 Inserm F-67400, and UMR7104 CNRS Illkirch, and Université de Strasbourg)

  • Petros Papadopoulos

    (Erasmus MC, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands)

  • Laszlo Tora

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 1 rue Laurent Fries, BP10142, 67404 Illkirch, and U964 Inserm F-67400, and UMR7104 CNRS Illkirch, and Université de Strasbourg)

  • Patrick Schultz

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 1 rue Laurent Fries, BP10142, 67404 Illkirch, and U964 Inserm F-67400, and UMR7104 CNRS Illkirch, and Université de Strasbourg)

  • Imre Berger

    (European Molecular Biology Laboratory (EMBL) Grenoble Outstation, and Unit of Virus Host Cell Interactions UVHCI, UJF-CNRS-EMBL Unité Mixte International UMI 3265, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9, France)

Abstract

The structures of three distinct human transcription factor IID (TFIID) protein assemblies are solved using cryo-electron microscopy; by incorporating TAF8 and TAF10, the key structural changes that remodel TFIID during assembly are determined, particularly the transition from a symmetric core-TFIID to an asymmetric holo-complex.

Suggested Citation

  • Christoph Bieniossek & Gabor Papai & Christiane Schaffitzel & Frederic Garzoni & Maxime Chaillet & Elisabeth Scheer & Petros Papadopoulos & Laszlo Tora & Patrick Schultz & Imre Berger, 2013. "The architecture of human general transcription factor TFIID core complex," Nature, Nature, vol. 493(7434), pages 699-702, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7434:d:10.1038_nature11791
    DOI: 10.1038/nature11791
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