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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

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  • Alejo Efeyan

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
    Massachusetts Institute of Technology
    David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, 77 Massachusetts Avenue)

  • Roberto Zoncu

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
    Massachusetts Institute of Technology
    David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, 77 Massachusetts Avenue)

  • Steven Chang

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
    Massachusetts Institute of Technology
    David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, 77 Massachusetts Avenue)

  • Iwona Gumper

    (New York University School of Medicine)

  • Harriet Snitkin

    (New York University School of Medicine)

  • Rachel L. Wolfson

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
    Massachusetts Institute of Technology
    David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, 77 Massachusetts Avenue)

  • Oktay Kirak

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Present address: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.)

  • David D. Sabatini

    (New York University School of Medicine)

  • David M. Sabatini

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
    Massachusetts Institute of Technology
    David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, 77 Massachusetts Avenue)

Abstract

Mice expressing a constitutively active form of RagA are unable to inhibit mTORC1 after birth and to trigger autophagy, and succumb perinatally.

Suggested Citation

  • Alejo Efeyan & Roberto Zoncu & Steven Chang & Iwona Gumper & Harriet Snitkin & Rachel L. Wolfson & Oktay Kirak & David D. Sabatini & David M. Sabatini, 2013. "Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival," Nature, Nature, vol. 493(7434), pages 679-683, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7434:d:10.1038_nature11745
    DOI: 10.1038/nature11745
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    Cited by:

    1. George K. E. Umanah & Leire Abalde-Atristain & Mohammed Repon Khan & Jaba Mitra & Mohamad Aasif Dar & Melissa Chang & Kavya Tangella & Amy McNamara & Samuel Bennett & Rong Chen & Vasudha Aggarwal & Ma, 2022. "AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Xing Chen & Chunyu Yu & Xinhua Liu & Beibei Liu & Xiaodi Wu & Jiajing Wu & Dong Yan & Lulu Han & Zifan Tang & Xinyi Yuan & Jianqiu Wang & Yue Wang & Shumeng Liu & Lin Shan & Yongfeng Shang, 2022. "Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Yanan Wang & Mengjun Luo & Fan Wang & Yu Tong & Linfeng Li & Yu Shu & Ke Qiao & Lei Zhang & Guoquan Yan & Jing Liu & Hongbin Ji & Youhua Xie & Yonglong Zhang & Wei-Qiang Gao & Yanfeng Liu, 2022. "AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Ana Belén Plata-Gómez & Lucía Prado-Rivas & Alba Sanz & Nerea Deleyto-Seldas & Fernando García & Celia Calle Arregui & Camila Silva & Eduardo Caleiras & Osvaldo Graña-Castro & Elena Piñeiro-Yáñez & Jo, 2024. "Hepatic nutrient and hormone signaling to mTORC1 instructs the postnatal metabolic zonation of the liver," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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