IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v493y2013i7434d10.1038_nature11729.html
   My bibliography  Save this article

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Author

Listed:
  • Michael T. Heneka

    (Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany
    Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE))

  • Markus P. Kummer

    (Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Andrea Stutz

    (Institute of Innate Immunity, University of Bonn)

  • Andrea Delekate

    (Zoological Institute, Technische Universität Braunschweig)

  • Stephanie Schwartz

    (Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Ana Vieira-Saecker

    (Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Angelika Griep

    (Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Daisy Axt

    (Clinical Neuroscience Unit, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany)

  • Anita Remus

    (Zoological Institute, Technische Universität Braunschweig)

  • Te-Chen Tzeng

    (University of Massachusetts Medical School)

  • Ellen Gelpi

    (Neurological Tissue Bank, University of Barcelona-Hospital Clinic, IDIBAPS, 08036 Barcelona, Spain)

  • Annett Halle

    (Center for Advanced European Studies and Research-CAESAR)

  • Martin Korte

    (Zoological Institute, Technische Universität Braunschweig
    Helmholtz-Center for Infection Research, HZI, AG NIND, 38124 Braunschweig, Germany)

  • Eicke Latz

    (Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
    Institute of Innate Immunity, University of Bonn
    University of Massachusetts Medical School)

  • Douglas T. Golenbock

    (University of Massachusetts Medical School)

Abstract

Alzheimer’s-prone mice deficient in NLRP3 or caspase-1 fail to develop learning deficits and show reduced neuropathology.

Suggested Citation

  • Michael T. Heneka & Markus P. Kummer & Andrea Stutz & Andrea Delekate & Stephanie Schwartz & Ana Vieira-Saecker & Angelika Griep & Daisy Axt & Anita Remus & Te-Chen Tzeng & Ellen Gelpi & Annett Halle , 2013. "NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice," Nature, Nature, vol. 493(7434), pages 674-678, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7434:d:10.1038_nature11729
    DOI: 10.1038/nature11729
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11729
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11729?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Dao-Gong Zhang & Wen-Qian Yu & Jia-Hui Liu & Li-Gang Kong & Na Zhang & Yong-Dong Song & Xiao-Fei Li & Zhao-Min Fan & Ya-Feng Lyu & Na Li & Hai-Bo Wang, 2023. "Serum/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Vicky Chou & Richard V. Pearse & Aimee J. Aylward & Nancy Ashour & Mariko Taga & Gizem Terzioglu & Masashi Fujita & Seeley B. Fancher & Alina Sigalov & Courtney R. Benoit & Hyo Lee & Matti Lam & Nicho, 2023. "INPP5D regulates inflammasome activation in human microglia," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    3. Ewa Rudnicka-Drożak & Paulina Drożak & Grzegorz Mizerski & Tomasz Zaborowski & Barbara Ślusarska & Grzegorz Nowicki & Martyna Drożak, 2023. "Links between COVID-19 and Alzheimer’s Disease—What Do We Already Know?," IJERPH, MDPI, vol. 20(3), pages 1-15, January.
    4. Noah R. Johnson & Peng Yuan & Erika Castillo & T. Peter Lopez & Weizhou Yue & Annalise Bond & Brianna M. Rivera & Miranda C. Sullivan & Masakazu Hirouchi & Kurt Giles & Atsushi Aoyagi & Carlo Condello, 2023. "CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    5. Loreta Strumylaite & Rima Kregzdyte & Odeta Kucikiene & Dale Baranauskiene & Vaida Simakauskiene & Rima Naginiene & Gyte Damuleviciene & Vita Lesauskaite & Reda Zemaitiene, 2022. "Alzheimer’s Disease Association with Metals and Metalloids Concentration in Blood and Urine," IJERPH, MDPI, vol. 19(12), pages 1-11, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:493:y:2013:i:7434:d:10.1038_nature11729. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.