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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Author

Listed:
  • Oliver D. K. Maddocks

    (The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK)

  • Celia R. Berkers

    (The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK)

  • Susan M. Mason

    (The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK)

  • Liang Zheng

    (The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK)

  • Karen Blyth

    (The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK)

  • Eyal Gottlieb

    (The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK)

  • Karen H. Vousden

    (The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK)

Abstract

The authors show that p53 helps cancer cells survive serine depletion by coordinating metabolic remodelling; a diet lacking serine slowed tumour growth in mice, with p53-null tumours showing greatest sensitivity to serine starvation.

Suggested Citation

  • Oliver D. K. Maddocks & Celia R. Berkers & Susan M. Mason & Liang Zheng & Karen Blyth & Eyal Gottlieb & Karen H. Vousden, 2013. "Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells," Nature, Nature, vol. 493(7433), pages 542-546, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7433:d:10.1038_nature11743
    DOI: 10.1038/nature11743
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    Cited by:

    1. A R Caseiro & G Ivanova & S S Pedrosa & M V Branquinho & P Georgieva & P P Barbosa & J D Santos & R Magalhães & P Teixeira & T Pereira & A C Maurício, 2018. "Human umbilical cord blood plasma as an alternative to animal sera for mesenchymal stromal cells in vitro expansion – A multicomponent metabolomic analysis," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-35, October.

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