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Functional and evolutionary insight from the crystal structure of rubella virus protein E1

Author

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  • Rebecca M. DuBois

    (Institut Pasteur, Unité de Virologie Structurale and CNRS URA 3015, F-75724 Paris Cedex 15, France)

  • Marie-Christine Vaney

    (Institut Pasteur, Unité de Virologie Structurale and CNRS URA 3015, F-75724 Paris Cedex 15, France)

  • M. Alejandra Tortorici

    (Institut Pasteur, Unité de Virologie Structurale and CNRS URA 3015, F-75724 Paris Cedex 15, France)

  • Rana Al Kurdi

    (Institut Pasteur, Unité de Virologie Structurale and CNRS URA 3015, F-75724 Paris Cedex 15, France)

  • Giovanna Barba-Spaeth

    (Institut Pasteur, Unité de Virologie Structurale and CNRS URA 3015, F-75724 Paris Cedex 15, France)

  • Thomas Krey

    (Institut Pasteur, Unité de Virologie Structurale and CNRS URA 3015, F-75724 Paris Cedex 15, France)

  • Félix A. Rey

    (Institut Pasteur, Unité de Virologie Structurale and CNRS URA 3015, F-75724 Paris Cedex 15, France)

Abstract

The crystal structure of rubella virus E1 glycoprotein in its post-fusion form reveals a class II fusion protein with distinct features so far unseen in any other crystallized fusion protein; the location of an antibody-neutralization epitope also suggests that rubella-specific antibodies may function through prevention of E1 glycoprotein trimer formation during cell entry.

Suggested Citation

  • Rebecca M. DuBois & Marie-Christine Vaney & M. Alejandra Tortorici & Rana Al Kurdi & Giovanna Barba-Spaeth & Thomas Krey & Félix A. Rey, 2013. "Functional and evolutionary insight from the crystal structure of rubella virus protein E1," Nature, Nature, vol. 493(7433), pages 552-556, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7433:d:10.1038_nature11741
    DOI: 10.1038/nature11741
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    Cited by:

    1. David Moi & Shunsuke Nishio & Xiaohui Li & Clari Valansi & Mauricio Langleib & Nicolas G. Brukman & Kateryna Flyak & Christophe Dessimoz & Daniele de Sanctis & Kathryn Tunyasuvunakool & John Jumper & , 2022. "Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Marie-Christine Vaney & Mariano Dellarole & Stéphane Duquerroy & Iris Medits & Georgios Tsouchnikas & Alexander Rouvinski & Patrick England & Karin Stiasny & Franz X. Heinz & Félix A. Rey, 2022. "Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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