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Dopamine neurons modulate neural encoding and expression of depression-related behaviour

Author

Listed:
  • Kay M. Tye

    (Picower Institute for Learning and Memory, Brain and Cognitive Sciences, Massachusetts Institute of Technology
    Stanford University)

  • Julie J. Mirzabekov

    (Stanford University)

  • Melissa R. Warden

    (Stanford University)

  • Emily A. Ferenczi

    (Stanford University
    Neurosciences Program, Stanford University)

  • Hsing-Chen Tsai

    (Stanford University
    Neurosciences Program, Stanford University)

  • Joel Finkelstein

    (Stanford University)

  • Sung-Yon Kim

    (Stanford University
    Neurosciences Program, Stanford University)

  • Avishek Adhikari

    (Stanford University)

  • Kimberly R. Thompson

    (Stanford University)

  • Aaron S. Andalman

    (Stanford University)

  • Lisa A. Gunaydin

    (Stanford University)

  • Ilana B. Witten

    (Stanford University)

  • Karl Deisseroth

    (Stanford University
    Neurosciences Program, Stanford University
    Stanford University, Stanford, California 94305, USA
    Howard Hughes Medical Institute, Stanford University)

Abstract

Specific manipulation of midbrain dopamine neurons in freely moving rodents shows that their inhibition or excitation immediately modulates depression-like phenotypes that are induced by chronic mild stress, and that their activation alters the neural encoding of depression-related behaviours in the nucleus accumbens.

Suggested Citation

  • Kay M. Tye & Julie J. Mirzabekov & Melissa R. Warden & Emily A. Ferenczi & Hsing-Chen Tsai & Joel Finkelstein & Sung-Yon Kim & Avishek Adhikari & Kimberly R. Thompson & Aaron S. Andalman & Lisa A. Gun, 2013. "Dopamine neurons modulate neural encoding and expression of depression-related behaviour," Nature, Nature, vol. 493(7433), pages 537-541, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7433:d:10.1038_nature11740
    DOI: 10.1038/nature11740
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    Citations

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    Cited by:

    1. Carole Morel & Sarah E. Montgomery & Long Li & Romain Durand-de Cuttoli & Emily M. Teichman & Barbara Juarez & Nikos Tzavaras & Stacy M. Ku & Meghan E. Flanigan & Min Cai & Jessica J. Walsh & Scott J., 2022. "Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Sorinel A Oprisan & Xandre Clementsmith & Tamas Tompa & Antonieta Lavin, 2019. "Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-39, October.
    3. Soo Hyun Yang & Esther Yang & Jaekwang Lee & Jin Yong Kim & Hyeijung Yoo & Hyung Sun Park & Jin Taek Jung & Dongmin Lee & Sungkun Chun & Yong Sang Jo & Gyeong Hee Pyeon & Jae-Yong Park & Hyun Woo Lee , 2023. "Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Yun-Feng Zhang & Jialiang Wu & Yingqi Wang & Natalie L. Johnson & Janardhan P. Bhattarai & Guanqing Li & Wenqiang Wang & Camilo Guevara & Hannah Shoenhard & Marc V. Fuccillo & Daniel W. Wesson & Mingh, 2023. "Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Thomas H. Lee & Malegaddi Devaki & Douglas A. Formolo & Julia M. Rosa & Andy S. K. Cheng & Suk-Yu Yau, 2023. "Effects of Voluntary Wheel Running Exercise on Chemotherapy-Impaired Cognitive and Motor Performance in Mice," IJERPH, MDPI, vol. 20(7), pages 1-17, April.
    6. Can Tao & Guang-Wei Zhang & Wen-Jian Sun & Junxiang J. Huang & Li I. Zhang & Huizhong Whit Tao, 2024. "Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    7. Weiping Dai & Mengqian Yang & Pei Xia & Chuan Xiao & Shuying Huang & Zhan Zhang & Xin Cheng & Wenchang Li & Jian Jin & Jingyun Zhang & Binghuo Wu & Yingying Zhang & Pei-hui Wu & Yangyang Lin & Wen Wu , 2022. "A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

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