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RNAi triggered by specialized machinery silences developmental genes and retrotransposons

Author

Listed:
  • Soichiro Yamanaka

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Sameet Mehta

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Francisca E. Reyes-Turcu

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Fanglei Zhuang

    (New England Biolabs)

  • Ryan T. Fuchs

    (New England Biolabs)

  • Yikang Rong

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Gregory B. Robb

    (New England Biolabs)

  • Shiv I. S. Grewal

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

Abstract

In the fission yeast Schizosaccharomyces pombe RNA interference (RNAi) machinery promotes heterochromatin assembly and silencing of centromeric repeats; here it is shown that RNAi participates in silencing other genomic regions, such as sexual differentiation genes and retrotransposons, and this process is regulated by developmental and environmental signals.

Suggested Citation

  • Soichiro Yamanaka & Sameet Mehta & Francisca E. Reyes-Turcu & Fanglei Zhuang & Ryan T. Fuchs & Yikang Rong & Gregory B. Robb & Shiv I. S. Grewal, 2013. "RNAi triggered by specialized machinery silences developmental genes and retrotransposons," Nature, Nature, vol. 493(7433), pages 557-560, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7433:d:10.1038_nature11716
    DOI: 10.1038/nature11716
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    Cited by:

    1. Komal Soni & Anusree Sivadas & Attila Horvath & Nikolay Dobrev & Rippei Hayashi & Leo Kiss & Bernd Simon & Klemens Wild & Irmgard Sinning & Tamás Fischer, 2023. "Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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