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Activity-dependent neuronal signalling and autism spectrum disorder

Author

Listed:
  • Daniel H. Ebert

    (Harvard Medical School
    Massachusetts General Hospital, Harvard Medical School)

  • Michael E. Greenberg

    (Harvard Medical School)

Abstract

Neuronal activity induces the post-translational modification of synaptic molecules, promotes localized protein synthesis within dendrites and activates gene transcription, thereby regulating synaptic function and allowing neuronal circuits to respond dynamically to experience. Evidence indicates that many of the genes that are mutated in autism spectrum disorder are crucial components of the activity-dependent signalling networks that regulate synapse development and plasticity. Dysregulation of activity-dependent signalling pathways in neurons may, therefore, have a key role in the aetiology of autism spectrum disorder.

Suggested Citation

  • Daniel H. Ebert & Michael E. Greenberg, 2013. "Activity-dependent neuronal signalling and autism spectrum disorder," Nature, Nature, vol. 493(7432), pages 327-337, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7432:d:10.1038_nature11860
    DOI: 10.1038/nature11860
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    Cited by:

    1. Andrew J. Best & Ulrich Braunschweig & Mingkun Wu & Shaghayegh Farhangmehr & Adrian Pasculescu & Justin J. Lim & Lim Caden Comsa & Mark Jen & Jenny Wang & Alessandro Datti & Jeffrey L. Wrana & Sabine , 2024. "High-throughput sensitive screening of small molecule modulators of microexon alternative splicing using dual Nano and Firefly luciferase reporters," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Stefano Berto & Alex H. Treacher & Emre Caglayan & Danni Luo & Jillian R. Haney & Michael J. Gandal & Daniel H. Geschwind & Albert A. Montillo & Genevieve Konopka, 2022. "Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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