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Prkcz null mice show normal learning and memory

Author

Listed:
  • Anna M. Lee

    (Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA)

  • Benjamin R. Kanter

    (Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA)

  • Dan Wang

    (Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA)

  • Jana P. Lim

    (Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA)

  • Mimi E. Zou

    (Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA)

  • Chichen Qiu

    (Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA)

  • Thomas McMahon

    (Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA)

  • Jahan Dadgar

    (Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA)

  • Sarah C. Fischbach-Weiss

    (Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA)

  • Robert O. Messing

    (Ernest Gallo Clinic and Research Center, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA)

Abstract

Genetically removing PKM-ζ in mice has no effect on memory, and despite absence of this kinase, the original peptide inhibitor of PKM-ζ still disrupts memory in these mutant mice; these data re-open the exploration for key molecules regulating maintenance of long-term plasticity processes.

Suggested Citation

  • Anna M. Lee & Benjamin R. Kanter & Dan Wang & Jana P. Lim & Mimi E. Zou & Chichen Qiu & Thomas McMahon & Jahan Dadgar & Sarah C. Fischbach-Weiss & Robert O. Messing, 2013. "Prkcz null mice show normal learning and memory," Nature, Nature, vol. 493(7432), pages 416-419, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7432:d:10.1038_nature11803
    DOI: 10.1038/nature11803
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