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Exaggerated translation causes synaptic and behavioural aberrations associated with autism

Author

Listed:
  • Emanuela Santini

    (Center for Neural Science, New York University)

  • Thu N. Huynh

    (Center for Neural Science, New York University)

  • Andrew F. MacAskill

    (Center for Neural Science, New York University)

  • Adam G. Carter

    (Center for Neural Science, New York University)

  • Philippe Pierre

    (Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université
    INSERM
    CNRS, URM 7280, Marseille 13288, France)

  • Davide Ruggero

    (School of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94143, USA)

  • Hanoch Kaphzan

    (Center for Neural Science, New York University
    Present address: Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa 31095, Israel.)

  • Eric Klann

    (Center for Neural Science, New York University)

Abstract

Mice overexpressing eIF4E show autism-related behaviours and altered synaptic activity in the hippocampus, prefrontal cortex and striatum, and these phenotypes can be rescued with the cap-dependent translation inhibitor 4EGI-1.

Suggested Citation

  • Emanuela Santini & Thu N. Huynh & Andrew F. MacAskill & Adam G. Carter & Philippe Pierre & Davide Ruggero & Hanoch Kaphzan & Eric Klann, 2013. "Exaggerated translation causes synaptic and behavioural aberrations associated with autism," Nature, Nature, vol. 493(7432), pages 411-415, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7432:d:10.1038_nature11782
    DOI: 10.1038/nature11782
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