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Mammalian heart renewal by pre-existing cardiomyocytes

Author

Listed:
  • Samuel E. Senyo

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Matthew L. Steinhauser

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Christie L. Pizzimenti

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Vicky K. Yang

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Lei Cai

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Mei Wang

    (National Resource for Imaging Mass Spectrometry
    Brigham and Women’s Hospital and Harvard Medical School)

  • Ting-Di Wu

    (INSERM U.759
    Institut Curie)

  • Jean-Luc Guerquin-Kern

    (INSERM U.759
    Institut Curie)

  • Claude P. Lechene

    (National Resource for Imaging Mass Spectrometry
    Brigham and Women’s Hospital and Harvard Medical School)

  • Richard T. Lee

    (Brigham and Women’s Hospital and Harvard Medical School
    Harvard Stem Cell Institute)

Abstract

During normal ageing a low rate of division of pre-existing cardiomyocytes, rather than progenitor cells, is responsible for cardiomyocyte genesis; this process is increased fourfold during myocardial infarction.

Suggested Citation

  • Samuel E. Senyo & Matthew L. Steinhauser & Christie L. Pizzimenti & Vicky K. Yang & Lei Cai & Mei Wang & Ting-Di Wu & Jean-Luc Guerquin-Kern & Claude P. Lechene & Richard T. Lee, 2013. "Mammalian heart renewal by pre-existing cardiomyocytes," Nature, Nature, vol. 493(7432), pages 433-436, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7432:d:10.1038_nature11682
    DOI: 10.1038/nature11682
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    Citations

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    Cited by:

    1. Jisheng Sun & Elizabeth A. Peterson & Xin Chen & Jinhu Wang, 2023. "hapln1a+ cells guide coronary growth during heart morphogenesis and regeneration," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Thomas Kisby & Irene de Lázaro & Maria Stylianou & Giulio Cossu & Kostas Kostarelos, 2021. "Transient reprogramming of postnatal cardiomyocytes to a dedifferentiated state," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-22, May.
    3. Rut Molinuevo & Julien Menendez & Kora Cadle & Nabeela Ariqat & Marie Klaire Choy & Cayla Lagousis & Gwen Thomas & Catherine Strietzel & J. W. Bubolz & Lindsay Hinck, 2024. "Physiological DNA damage promotes functional endoreplication of mammary gland alveolar cells during lactation," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    4. Carmen Sena-Tomás & Angelika G. Aleman & Caitlin Ford & Akriti Varshney & Di Yao & Jamie K. Harrington & Leonor Saúde & Mirana Ramialison & Kimara L. Targoff, 2022. "Activation of Nkx2.5 transcriptional program is required for adult myocardial repair," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Cornelis J. Boogerd & Ilaria Perini & Eirini Kyriakopoulou & Su Ji Han & Phit La & Britt Swaan & Jari B. Berkhout & Danielle Versteeg & Jantine Monshouwer-Kloots & Eva Rooij, 2023. "Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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