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How insulin engages its primary binding site on the insulin receptor

Author

Listed:
  • John G. Menting

    (Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia)

  • Jonathan Whittaker

    (School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA)

  • Mai B. Margetts

    (Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia)

  • Linda J. Whittaker

    (School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA)

  • Geoffrey K.-W. Kong

    (Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia)

  • Brian J. Smith

    (Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia)

  • Christopher J. Watson

    (York Structural Biology Laboratory, University of York)

  • Lenka Žáková

    (Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 16610 Prague, Czech Republic)

  • Emília Kletvíková

    (Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 16610 Prague, Czech Republic)

  • Jiří Jiráček

    (Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 16610 Prague, Czech Republic)

  • Shu Jin Chan

    (University of Chicago, Chicago, Illinois 60637, USA)

  • Donald F. Steiner

    (University of Chicago, Chicago, Illinois 60637, USA)

  • Guy G. Dodson

    (York Structural Biology Laboratory, University of York)

  • Andrzej M. Brzozowski

    (York Structural Biology Laboratory, University of York)

  • Michael A. Weiss

    (School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA)

  • Colin W. Ward

    (Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia)

  • Michael C. Lawrence

    (Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    University of Melbourne, Royal Parade, Parkville, Victoria 3010, Australia)

Abstract

The three-dimensional structure of the insulin–insulin receptor complex has proved elusive, confounded by the complexity of producing the receptor protein; here is the first glimpse of the interaction between insulin and its primary binding site on the insulin receptor, a view based on four crystal structures of insulin bound to truncated insulin receptor complexes.

Suggested Citation

  • John G. Menting & Jonathan Whittaker & Mai B. Margetts & Linda J. Whittaker & Geoffrey K.-W. Kong & Brian J. Smith & Christopher J. Watson & Lenka Žáková & Emília Kletvíková & Jiří Jiráček & Shu Jin C, 2013. "How insulin engages its primary binding site on the insulin receptor," Nature, Nature, vol. 493(7431), pages 241-245, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7431:d:10.1038_nature11781
    DOI: 10.1038/nature11781
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    Cited by:

    1. Junhee Park & Jie Li & John P. Mayer & Kerri A. Ball & Jiayi Wu & Catherine Hall & Domenico Accili & Michael H. B. Stowell & Xiao-chen Bai & Eunhee Choi, 2022. "Activation of the insulin receptor by an insulin mimetic peptide," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Junhong Kim & Na-Oh Yunn & Mangeun Park & Jihan Kim & Seongeun Park & Yoojoong Kim & Jeongeun Noh & Sung Ho Ryu & Yunje Cho, 2022. "Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Weidong An & Catherine Hall & Jie Li & Albert Hung & Jiayi Wu & Junhee Park & Liwei Wang & Xiao-chen Bai & Eunhee Choi, 2024. "Activation of the insulin receptor by insulin-like growth factor 2," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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