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COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis

Author

Listed:
  • Jun Qin

    (Baylor College of Medicine)

  • San-Pin Wu

    (Baylor College of Medicine)

  • Chad J. Creighton

    (Dan L. Duncan Cancer Center, Baylor College of Medicine)

  • Fangyan Dai

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Xin Xie

    (Baylor College of Medicine)

  • Chiang-Min Cheng

    (Baylor College of Medicine)

  • Anna Frolov

    (Baylor College of Medicine)

  • Gustavo Ayala

    (Baylor College of Medicine
    Present address: Department of Pathology and Laboratory Medicine, University of Texas Health Science Center Medical School, Houston, Texas 77030, USA.)

  • Xia Lin

    (Baylor College of Medicine)

  • Xin-Hua Feng

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Michael M. Ittmann

    (Baylor College of Medicine)

  • Shaw-Jenq Tsai

    (Baylor College of Medicine
    College of Medicine, National Cheng Kung University, Tainan 701, Taiwan)

  • Ming-Jer Tsai

    (Baylor College of Medicine
    Program in Developmental Biology, Baylor College of Medicine)

  • Sophia Y. Tsai

    (Baylor College of Medicine
    Program in Developmental Biology, Baylor College of Medicine)

Abstract

A cell-autonomous role for the COUP-TFII transcription factor in prostate cancer cells is identified, in which COUP-TFII inhibits TGF-β signalling by binding to SMAD4; COUP-TFII promotes prostate tumorigenesis and metastasis in a mouse model, and is associated with more aggressive disease in human prostate cancers.

Suggested Citation

  • Jun Qin & San-Pin Wu & Chad J. Creighton & Fangyan Dai & Xin Xie & Chiang-Min Cheng & Anna Frolov & Gustavo Ayala & Xia Lin & Xin-Hua Feng & Michael M. Ittmann & Shaw-Jenq Tsai & Ming-Jer Tsai & Sophi, 2013. "COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis," Nature, Nature, vol. 493(7431), pages 236-240, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7431:d:10.1038_nature11674
    DOI: 10.1038/nature11674
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    Cited by:

    1. Ni Li & Qiuli Liu & Ying Han & Siyu Pei & Bisheng Cheng & Junyu Xu & Xiang Miao & Qiang Pan & Hanling Wang & Jiacheng Guo & Xuege Wang & Guoying Zhang & Yannan Lian & Wei Zhang & Yi Zang & Minjia Tan , 2022. "ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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