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Scaling of embryonic patterning based on phase-gradient encoding

Author

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  • Volker M. Lauschke

    (Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany)

  • Charisios D. Tsiairis

    (Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany)

  • Paul François

    (McGill University)

  • Alexander Aulehla

    (Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany)

Abstract

An ex vivo primary culture assay is developed that recapitulates mouse embryonic mesodermal patterning and segment formation; using this approach, it is shown that oscillating gene activity is central to maintain stable proportions during development.

Suggested Citation

  • Volker M. Lauschke & Charisios D. Tsiairis & Paul François & Alexander Aulehla, 2013. "Scaling of embryonic patterning based on phase-gradient encoding," Nature, Nature, vol. 493(7430), pages 101-105, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7430:d:10.1038_nature11804
    DOI: 10.1038/nature11804
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    Cited by:

    1. Marina Sanaki-Matsumiya & Mitsuhiro Matsuda & Nicola Gritti & Fumio Nakaki & James Sharpe & Vikas Trivedi & Miki Ebisuya, 2022. "Periodic formation of epithelial somites from human pluripotent stem cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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