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Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells

Author

Listed:
  • Alexej Abyzov

    (Program in Neurodevelopment and Regeneration, Yale University
    Program in Computation Biology and Bioinformatics, Yale University
    Yale University)

  • Jessica Mariani

    (Program in Neurodevelopment and Regeneration, Yale University
    Child Study Center, Yale University)

  • Dean Palejev

    (Program in Neurodevelopment and Regeneration, Yale University
    Child Study Center, Yale University)

  • Ying Zhang

    (Program in Neurodevelopment and Regeneration, Yale University
    Yale University)

  • Michael Seamus Haney

    (Stanford University
    School of Medicine, Stanford University)

  • Livia Tomasini

    (Program in Neurodevelopment and Regeneration, Yale University
    Child Study Center, Yale University)

  • Anthony F. Ferrandino

    (Program in Neurodevelopment and Regeneration, Yale University
    Child Study Center, Yale University)

  • Lior A. Rosenberg Belmaker

    (Program in Neurodevelopment and Regeneration, Yale University
    Child Study Center, Yale University)

  • Anna Szekely

    (Program in Neurodevelopment and Regeneration, Yale University
    Yale University
    Yale University)

  • Michael Wilson

    (Program in Neurodevelopment and Regeneration, Yale University
    Program in Computation Biology and Bioinformatics, Yale University
    Child Study Center, Yale University)

  • Arif Kocabas

    (Program in Neurodevelopment and Regeneration, Yale University
    Child Study Center, Yale University)

  • Nathaniel E. Calixto

    (Program in Neurodevelopment and Regeneration, Yale University
    Child Study Center, Yale University)

  • Elena L. Grigorenko

    (Program in Neurodevelopment and Regeneration, Yale University
    Child Study Center, Yale University
    Yale University
    Yale University)

  • Anita Huttner

    (Program in Neurodevelopment and Regeneration, Yale University
    Yale University)

  • Katarzyna Chawarska

    (Program in Neurodevelopment and Regeneration, Yale University
    Child Study Center, Yale University)

  • Sherman Weissman

    (Program in Neurodevelopment and Regeneration, Yale University
    Yale University)

  • Alexander Eckehart Urban

    (Program in Neurodevelopment and Regeneration, Yale University
    Stanford University
    School of Medicine, Stanford University)

  • Mark Gerstein

    (Program in Neurodevelopment and Regeneration, Yale University
    Program in Computation Biology and Bioinformatics, Yale University
    Yale University
    Yale University)

  • Flora M. Vaccarino

    (Program in Neurodevelopment and Regeneration, Yale University
    Child Study Center, Yale University
    Yale University)

Abstract

A whole-genome and transcriptome analysis of 20 human induced pluripotent stem-cell lines shows that reprogramming does not necessarily add de novo copy number variants to what is already present in the somatic cells from which they originated.

Suggested Citation

  • Alexej Abyzov & Jessica Mariani & Dean Palejev & Ying Zhang & Michael Seamus Haney & Livia Tomasini & Anthony F. Ferrandino & Lior A. Rosenberg Belmaker & Anna Szekely & Michael Wilson & Arif Kocabas , 2012. "Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells," Nature, Nature, vol. 492(7429), pages 438-442, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7429:d:10.1038_nature11629
    DOI: 10.1038/nature11629
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    Cited by:

    1. Sriram Vijayraghavan & Thomas Blouin & James McCollum & Latarsha Porcher & François Virard & Jiri Zavadil & Carol Feghali-Bostwick & Natalie Saini, 2024. "Widespread mutagenesis and chromosomal instability shape somatic genomes in systemic sclerosis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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