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Layered reward signalling through octopamine and dopamine in Drosophila

Author

Listed:
  • Christopher J. Burke

    (University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA)

  • Wolf Huetteroth

    (Centre for Neural Circuits and Behaviour, The University of Oxford, Tinsley Building, Mansfield Road, Oxford OX1 3SR, UK)

  • David Owald

    (Centre for Neural Circuits and Behaviour, The University of Oxford, Tinsley Building, Mansfield Road, Oxford OX1 3SR, UK)

  • Emmanuel Perisse

    (Centre for Neural Circuits and Behaviour, The University of Oxford, Tinsley Building, Mansfield Road, Oxford OX1 3SR, UK)

  • Michael J. Krashes

    (University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Present address: Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Sciences, 3 Blackfan Circle, Boston, Massachusetts 02215, USA.)

  • Gaurav Das

    (Centre for Neural Circuits and Behaviour, The University of Oxford, Tinsley Building, Mansfield Road, Oxford OX1 3SR, UK)

  • Daryl Gohl

    (Stanford University)

  • Marion Silies

    (Stanford University)

  • Sarah Certel

    (University of Montana)

  • Scott Waddell

    (University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Centre for Neural Circuits and Behaviour, The University of Oxford, Tinsley Building, Mansfield Road, Oxford OX1 3SR, UK)

Abstract

Dopamine is synonymous with reward in mammals but associated with aversive reinforcement in insects, where reward seems to be signalled by octopamine; here it is shown that flies have discrete populations of dopamine neurons representing positive or negative values that are coordinately regulated by octopamine.

Suggested Citation

  • Christopher J. Burke & Wolf Huetteroth & David Owald & Emmanuel Perisse & Michael J. Krashes & Gaurav Das & Daryl Gohl & Marion Silies & Sarah Certel & Scott Waddell, 2012. "Layered reward signalling through octopamine and dopamine in Drosophila," Nature, Nature, vol. 492(7429), pages 433-437, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7429:d:10.1038_nature11614
    DOI: 10.1038/nature11614
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    Cited by:

    1. Fangmin Zhou & Alexandra-Madelaine Tichy & Bibi Nusreen Imambocus & Shreyas Sakharwade & Francisco J. Rodriguez Jimenez & Marco González Martínez & Ishrat Jahan & Margarita Habib & Nina Wilhelmy & Van, 2023. "Optimized design and in vivo application of optogenetically functionalized Drosophila dopamine receptors," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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